摘要
The [2] pseudorotaxane of cucurbit[6]uril(CB[6]) with guest molecule 1,6-bis(imidazol-1-yl)hexane dihydrochloride(BIMH-Cl) made pBR322 DNA hydrolyzed efficiently in physiological environment. The cleavage mechanism was proposed that was a cooperation process of the CB[6] molecule and the guest BIMH molecule. In this mechanism, the protonated imidazole might bind DNA via the electrostatic interactions and the CB[6] glycoluril carbonyl oxygen atoms activated a water molecule to attack the phosphorus atom.
The [ 2 ] pseudorotaxane of cucurbit [ 6 ] uril （ CB [ 6 ] ） with guest molecule 1,6-bis （ imidazol- 1 -yl） hexane dihydrochloride（BIMH-Cl） made pBR322 DNA hydrolyzed efficiently in physiological environment. The cleavage mechanism was proposed that was a cooperation process of the CB [ 6 ] molecule and the guest BIMH molecule. In this mechanism, the protonated imidazole might bind DNA via the electrostatic interactions and the CB [ 6 ] glycoluril carbonyl oxygen atoms activated a water molecule to attack the phosphorus atom.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第5期894-896,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:30470408)资助.
关键词
瓜环
准轮烷
晶体结构
DNA切割
Cucurbituril
Pseudorotaxane
Crystal structure
DNA Cleavage
