反式白藜芦醇对D-半乳糖致老大鼠骨质影响研究

Influence of trans-resveratrol on osseous changes in D-galactose induced aging rats

目的研究反式白藜芦醇对D-半乳糖致老大鼠骨质的影响。方法用D-半乳糖注射Wistar雄性大鼠5个月,建立衰老模型。对青年组、模型组、药物组(高、中、低剂量)和正常老龄对照组骨常规参数进行测定及比较。结果模型组骨常规参数中骨密度、结构力学参数、生物力学参数、钙、镁、锰及羟脯氨酸含量均比青年组有显著降低(P＜0.01),而骨磷含量比青年组有显著升高(P＜0.01),这些变化与正常老龄对照组的变化趋势一致,并比后者变化得更显著。相比之下,不同剂量药物组上述参数指标与模型组比较均呈现显著差异(P＜0.01)。结论长期大量摄入D-半乳糖导致大鼠衰老的同时可能并发骨质疏松症,而反式白藜芦醇可以延缓此类致老骨质疏松症的发生。

Objective To study the influence of trans-resveratrol on D-galactose induced osseous changes of rats. Methods Wistar rats were given injections of D-galactose for 5 months to cause aging. Osseous routine parameters were tested and compared in young group, model group, medication groups （highdoes, middle-does, low-does） and normal old group. Results Compared with young group, the bone mineral density （ BMD）, structural mechanics parameters of bone, biomechanics parameters of bone, bone calcium, manganese, magnesium and the content of hydroxyproline in the model group were significantly decreased （P 〈0.01 ）. However, bone phosphorus was significantly raised（P 〈0.01 ）. Those changes of the model group were the same as those of the old group, but the changes of the different medication group significantly differed with the model group. Conclusion The high does of D-galactose can cause aging and osteoporosis at the same time, and trans-resveratrol can delay D-galactose induced osseous changes.