肝细胞癌患者血清瘦素表达及其临床意义

Clinical significance and expression of serum leptin in primary hepatocarcinoma

目的探讨肝细胞癌患者血清Lep的表达和临床意义。方法用ELISA检测30例健康对照、31例肝硬化和146例HCC患者血清Lep含量,分析Lep在HCC临床分期及预后的关系。结果HCC患者血清Lep水平与BMI高度相关,Lep水平(ng/ml)HCC组(19.16±8.65)与肝硬化组(34.62±13.87)和健康对照组(27.41±11.72)比较差异有显著性(P<0.05),且性别差异明显(P<0.01),女性约为男性的2倍。随HCC患者TNM分期增加和转移、复发,其血清Lep水平明显降低(P<0.05)。结论血清Lep水平可作为判断HCC患者营养状况和预后的重要指标。

Objective To explore the clinical significance and expression of serum leptin in HCC.Methods By using ELISA serum Leptin levels were determined in 146 patients with HCC, 31 patients with liver cirrhosis and 30 healthy control. The relationship among Leptin and clinical stages and prognostic were analyzed.Results The serum Leptin levels （19.16± 8.65 ng/ml） was significantly correlated to BMI in HCC group,and were significantly lower than those in liver cirrhosis group （34.62±13.87 ng/ml）and in healthy control group（27.41± 11.72 ng/ml）（P〈0.05）,which showed 1 time higher in womem than in men. The serum Leptin levels in HCC group were significantly lower with upgrade of TNM stage,transfer and recrudesce （P〈 0.05）.Conclusion It is suggested that the detection of serum leptin might reflect nutritional status of the patients with primary hepatocarcinoma and a predictor of prognosis.