摘要
在苯溶液中,将2-(2-甲酰基苯氧基)乙酸与二正丁基氧化锡进行脱水反应,获得二正丁基锡二2-(2-甲酰基苯氧基)乙酸酯(1),并经过元素分析、1H NMR和IR及晶体结构测试技术进行了结构表征。结果表明,晶体属于C2/c空间群,晶胞参数:a=3.324 6(7)nm,b=0.484 54(10)nm,c=2.214 7(5)nm,β=131.373(2)°,V=2.677 3(9)nm3,Z=4,F(000)=1 208,Dc=1.467 g/cm3,μ=0.999 mm-1,R1=0.048 8,wR2=0.104 8。结构单元内包含1个独立分子,形成以六配位锡为中心的斜梯形双棱锥构型;分子间的Sn O(0.346 8 nm)配位作用,中心锡原子为八配位,构成以锡为中心的扭曲的六方双锥构型的一维链状桥环化合物。杀菌活性顺序为:化合物1>二丁基氧化锡>2-(2-甲酰基苯氧基)乙酸。
Di-n-butyhin di-2-(2-formylphenoxy)acetic ester(1 ) was synthesized by the reaction of di-n-butyl tin oxide with 2-(2-formylphenoxy)acetic acid and azeotropic removal of water with benzene. The compound was characterized by elemental analysis, ^1H NMR, FT-IR, and single crystal X-ray diffraction analysis. The crystal belongs to space group C2/c, and the cell parameter are : a = 3.324 6 (7) nm, b = 0. 484 54 (10) nm, c =2. 214 7(5) nm,β = 131. 373(2) °, V=2. 677 3(9) m^3, Z =4, F(000) = 1 208 ,Dc = 1. 467 g/cm^4, μ =0. 999 nm^-1, R1 =0. 048 and wR2 =0. 104 8. There is one molecule in the unit cell, which adopts a skew-trapezoidal bipyramidal arrangement around the tin atom with hexa-coordination; in addition, there are weak bridging intermolecular Sn…O (0. 346 8 nm) interactions, and the endocyclic Sn atom is octa-coordinated and exists in distorted hexagonal bipyramidal geometry in a one-dimensional chain. The complex (1) exhibits good antibacterial properties, while the antibacterial activity decreased in the order of compound (1) 〉 di-n-butyhin oxide 〉 2 - ( 2 -formylphenoxy )acetic acid.
出处
《应用化学》
CAS
CSCD
北大核心
2007年第6期660-664,共5页
Chinese Journal of Applied Chemistry
基金
黑龙江省杰出青年科学基金(J03-11)
黑龙江省省教育厅海外学人项目(1055HZ034)资助项目
关键词
有机锡
(甲酰基苯氧基)乙酸
合成
晶体结构
六方双锥构型
一维链
杀菌活性
organotin, (formylphenoxy) acetic acid, synthesis, crystal structure, hexagonal bipyramidal geometry, one-dimensional chain, antibacterial activity