CAG方案治疗老年急性髓细胞白血病疗效观察
被引量:3
摘要
随着人均寿命延长,老年性急性白血病有上升的趋势,其中以急性髓细胞白血病(AML)为多见。老年AML(60岁以上)具有不同的特点和转归,与60岁以下的AML相比,全身耐受性差,并发症多。老年AML患者因继发性AML多见,如继发于骨髓增生异常综合症(MDS)病史或其他血液病史,故治疗效果不理想。2002年以来本院采用小剂量阿糖胞苷(Ara—C)、阿克拉霉素(Acla)联合粒细胞集落刺激因子(G—CSF)组成的CAG方案治疗12例老年性AML,取得了较好的疗效,现报道如下。
出处
《浙江医学》
CAS
2007年第5期508-509,共2页
Zhejiang Medical Journal
参考文献7
-
1全国白血病化学治疗讨论会.急性白血病疗效标准[J].中华血液学杂志,1988,9(3):183-183.
-
2许晓华,张晓红,朱康儿,徐炀,黄连生,吴东,童杰峰.自体造血干细胞移植治疗恶性肿瘤15例临床观察[J].浙江医学,2002,24(12):732-733. 被引量:3
-
3Yamada K,Furusawa S,Saito K,et al.Concurrent use of granulocyte colony-stimulating factor with lower-dose cytosine arabinoside and aclarubicin for previously treated acute myelogenous leukemia:a pilot study[J].Leukemia,1995,9(1):10-14.
-
4Saito K,Nakamura Y,Aoyagi M,et al.Lower-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor(CAG regimen)for previously treated patients with relapsed or primary resistant acute myelogenous leukemia(AML) and previously untreated elderly patients with AML,secondary AML,and refractory anemia with excess blasts in transformation[J].Int J Hematol,2000,71(3):238-244.
-
5陆化,李建勇,葛峥,张晓艳,钱思轩,张建富,吴雨洁.CAG方案治疗老年急性髓细胞白血病疗效分析[J].实用老年医学,2004,18(5):277-278. 被引量:5
-
6Bai A,Kojima H,Hori M,et al.Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells[J].Exp Hematol,1999,27(2):259-265.
-
7Akashi K,Eto T,Shibuya T,et al.Aclarubicin induces differentiation of leukemia progenitors in myelodysplastic syndrome cooperating with granulocyte colony-stimulating factor[J].Leuk Res,2000,24(3):243-248.
二级参考文献9
-
1Rodrigues CA,Chauffaille ML,Pelloso LA,et al.Acute myeloid leukemia in elderly patients:experience of a single center[J].Braz J Med Biol Res,2003,36(6):703
-
2Behringer B,Pitako JA,Kunzmann R,et al.Prognosis of older patients with acute myeloid leukemia receiving either induction or noncurative treatment:a single-center retrospective study[J].Ann Hematol,2003,82(7):318
-
3Hirayama Y,Sakamaki S,Takayangai N,et al.Chemotherapy with ubenimex corresponding to patient age and organ disorder for 18 cases of acute myelogeneous leukemia in elderly patients-effects,complicatons and long-term survival[J].Gan To Kagaku Ryoho,2003,30(8):1113
-
4Gratwohl,Hermans J,Baldomero S,et al. Blood and marrow transplantation activity in Europe 1995. Bone Marrow Transplant, 1997, 19:407.
-
5Karel A, Dicke J. Double intensification including autologous bone marrow transplantation in AML. Bone Marrow Transplant, 1990,6: 27.
-
6Weaver CH,Schwartzberg L,Zhen B,et al. High-dose chemotherapy and peripheral blood stem cell infusion in patients with non-Hodgkin's lymphoma, results of out-patient treatment in community cancer centers. Bone Morrow Transplant, 1997,20: 753.
-
7Koppler H. Haemopoietic stem cell recorrery after high-dose chemotherapy and no slow freezing autolegous marrow transplant. Ann Hematol,1991,63: 253.
-
8Gratwohl A. Blood and marrow transplantation activity in Europe 1996, Bone Marrow Transplant, 1998,22: 227.
-
9胡增祥,张伯龙,楼方定,周绮,于力,高春记.自体外周血造血干细胞移植治疗恶性淋巴瘤16例临床分析[J].临床血液学杂志,2000,13(5):195-197. 被引量:11
共引文献54
-
1何玲,邓莉莉.急性髓细胞白血病缓解后联用大剂量阿糖胞苷化疗的临床疗效观察[J].临床医学,2004,24(7):1-2. 被引量:2
-
2胡永军,滕熔.白血病细胞检测WT1mRNA及其蛋白产物的价值与意义[J].中国血液流变学杂志,2004,14(4):448-451.
-
3郑君议,陈建斌.米托蒽醌联合阿糖胞苷诱导治疗成人初治急性髓细胞性白血病疗效分析[J].重庆医学,2005,34(9):1301-1303. 被引量:5
-
4李春,沈柏钧.儿童急性淋巴细胞性白血病人白细胞抗原表达及免疫功能探讨[J].中国基层医药,2005,12(9):1137-1138. 被引量:2
-
5唐旭东,唐由君.急性白血病患者预后相关的临床病理学因素[J].肿瘤防治杂志,2005,12(21):1673-1676.
-
6刘文,李峰敏,郭媛媛,宋辉,黄淑贤,左继爽.CAG方案治疗难治、复发性急性髓系白血病的临床疗效[J].中国煤炭工业医学杂志,2006,9(4):362-363. 被引量:5
-
7葛素梅,谢平,谢可鸣,沈云峰,顾中华,穆会君,王珏,张滨.葡萄糖神经酰胺合成酶在人白血病细胞中的表达及其与多药耐药的关系[J].苏州大学学报(医学版),2006,26(3):386-388.
-
8韩洁英,陈芳源,王婷,黄洪晖,韩晓凤,沈莉菁,欧阳仁荣.大剂量阿糖胞苷巩固治疗急性髓细胞白血病后无病生存分析[J].临床血液学杂志,2006,19(5):287-288. 被引量:3
-
9钱红兰,沈志坚,胡旭东,陈怡,梁彬,俞康.Priming Therapy方案治疗难治复发性急性髓性白血病的临床研究[J].浙江临床医学,2006,8(9):914-915.
-
10邵彬,高彦荣,王椿,颜式可,蔡琦,姜杰玲,白海涛,赵旻.老年急性髓系白血病个体化治疗探讨[J].临床血液学杂志,2006,19(6):323-326. 被引量:4
同被引文献11
-
1陆化,李建勇,葛峥,张晓艳,钱思轩,张建富,吴雨洁.CAG方案治疗老年急性髓细胞白血病疗效分析[J].实用老年医学,2004,18(5):277-278. 被引量:5
-
2孙慧平,刘伟红,李军民,陈秋生,陈瑜,陈颖,沈志祥.IA联合CAG方案序贯诱导缓解治疗原发性初治急性髓系白血病[J].白血病.淋巴瘤,2006,15(6):425-427. 被引量:9
-
3Yamada K,Fumsawa S,Saito Ket al.Concurrentuse use of granulocyte Colony-stimulating factor with low-dose cytosine arabinosideand aclabingcin for previously treated acute mydogenous leukemia:a pilot study[J].Leukemia,1995,9(6):10-14.
-
4周盾,黄河.血液内科学[M].北京:人民卫生出版社,2009:34-35.
-
5Yamada K,Furusawa S,Saito K,et al.Concurrent use of granulocyte colony stimulating factor with low-dose cytosine arabinoside and aclarubicin for previously treated acute myelogenous leukemia:a pilot study[J].Leukemia,1995,9(1):10-14.
-
6Cheson BD,Bennett JM,Kopecky KJ,et al.Revised recommendationsof the International Working Group for diagnosis,standardization of response criteria,treatment outcomes,and reporting standards for therapeutic trials in acute myeloid leukemia[J].J Clin Oncol,2003,21(24):4642-4649.
-
7Yamada K,Fumsawa S,Saito K,et al.Concurrentuse use of granulocyte Colony-stimulating factor with low-dose cytosine arabinosideand aclabingcin for previously treated acute mydogenousleukemia:a pilot study[J].Leukemia,1995,9(6):10-14.
-
8Amadori S, Suciu S, Jehn U, et al. Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in palients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study. Blood, 2005, 106: 27-34.
-
9Witz F, Sadoun A, Perin MC. et al. A placebo-contrnlled study of recombinant human granulncyte-macrophage colony-stimulating factor administered during and after induction trealment for de novo acute myelogennus leukemia in elderly patients. Grnupe Ouest Est Leuc6mies Aigus My61oblastiques (GOELAM). Blood, 1998, 91: 2722-2730.
-
10Yamada K, Shirakawa S, Ohno R, et al. A phase Ⅱ study of (2R)-4- 0-tetrahydrupyranyladriamycin (THP) in hematological malignancies.Invest New Drugs, 1987.5: 299-305.
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-
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-
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-
3叶筱颖.老年初治急性髓细胞白血病32例临床分析[J].当代医学,2015,21(18):88-89. 被引量:2
-
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-
2朱宁,吴斌,黄发清,李先梅,张晓莲,薛彬.小剂量AA方案治疗急性髓系白血病2例报告[J].中国民康医学,2006,18(18):673-673.
-
3孟小莉.阿克拉霉素联合阿糖胞苷对survivin基因表达的原代急性白血病细胞增殖的影响[J].郑州大学学报(医学版),2006,41(6):1145-1146. 被引量:1
-
4韩洁英,陈芳源,钟华,胡霄飞,韩晓凤,沈莉菁,欧阳仁荣.CAG方案治疗复发、难治和继发性急性髓细胞白血病疗效观察[J].上海医学,2003,26(6):289-291. 被引量:13
-
5李菁媛,冉启杰,周敏,罗晓静,谢红,张新华.改良CAG方案治疗高细胞急性髓系白血病疗效观察[J].中国医药导刊,2012,14(6):992-993. 被引量:8
-
6王凤清,刘艳春.艾迪注射液联合CAG方案治疗老年急性髓细胞白血病40例疗效观察[J].西部中医药,2012,25(12):85-87. 被引量:6
-
7孟小莉.原代白血病细胞存活蛋白(Survivin)基因表达与化疗敏感性[J].中国实验血液学杂志,2005,13(2):266-268. 被引量:1
-
8姚鲲,刘卓刚.CAG方案治疗低增生性急性髓系白血病29例[J].白血病.淋巴瘤,2011,20(2):98-99. 被引量:3
-
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-
10李秀瑾.阿糖胞苷、阿克拉霉素联合G-CSF治疗复发急性髓系白血病的临床研究[J].中国现代药物应用,2015,9(11):120-121.