冠心病患者血脂代谢异常的流行病学研究

Epidemiology of serum lipid abnormality in patients with coronary artery disease

目的探讨冠心病患者血脂水平以及血脂代谢异常的流行情况。方法将2005年6月至9月来自北京市、上海市等7城市52家医院心内科所有符合冠心病诊断标准的患者连续入选，共收集有效病例3513例，调查其血脂代谢情况。结果研究对象的血脂代谢异常总发生率为79．7％，〈50岁组、50～59岁组、60—69岁组和≥70岁组分别为90．6％，86，9％，80．0％和72．5％，趋势检验差异具有显著性意义（X^2=62．359，P〈0．001）。随着年龄的增加总胆固醇（TC）异常、低密度脂蛋白（LDL—C）异常、高密度脂蛋白（HDL—C）异常以及三酰甘油（TG）异常的发生率降低；总的血脂代谢异常发生率亦呈现同样趋势。结论冠心病患者血脂代谢异常发生率较高，尤其是50岁以下患者，应该尽早预防高血脂，从而改善冠心病患者的预后甚至防止冠心病的发生。

Objective To investigate the lipidemia of patients with coronary artery disease （CAD） in China. Methods The survey engaged 52 centers in 7 cities in China recruiting patients with coronary artery disease in a hospital-based setting. Each center was asked to recruit all hospitalized patients with CHD from 1-Jun-2005 to 31-Sep-2005. The study population consisted of 3513 patients with CAD. Results Of the 3513 patients,the prevalence of the lipidemia was 79. 7%. And the prevalence of the lipidemia in 〈 50,50 to 59,60 to 69, ≥ 70 years group was 90. 6%, 86. 9%, 80. 0% and 72.5% ,respectively. Trend test found that there was significant difference among them（ X^2 = 62. 359 ,P〈 0. 001 ）. There was a clear age-related decrease in the prevalence of lipidemia in the CAD patients. Conclusion Our results demonstrate a high prevalence of the lipidemia in patients with coronary heart disease, especially in 〈 50 years group. Screening for the lipidemia in young patients may prevent progressive CAD.