酒依赖患者认知功能障碍临床研究

The cognitive impairment of patients with alcohol dependence

目的评估慢性酒依赖患者的认知功能状况。方法分别应用韦氏成人智力量表和韦氏记忆量表,对53例男性酒依赖患者和34名匹配的正常对照组进行智能和记忆功能的评定,比较两组之间的差异,并对酒依赖患者认知功能损害的危险因素进行相关分析。结果慢性酒依赖者的智商为(86.03±9.87),记忆商为(61.07±10.13),均显著低于对照组(P<0.01);智能和记忆量表的各因子分均低于对照组P<0.05或0.01)。相关分析显示:慢性酒依赖患者的智商和记忆商数与饮酒时间呈显著负相关(r=0.4,P<0.01),与教育程度及习惯性饮酒开始年龄呈正相关(r=0.2,P>0.05)。结论慢性酒依赖患者存在显著的认知功能障碍。

Objective To evaluate the cognitive status of alcohol dependence. Methods Intelligence and remembrance were assessed using the Wechsler Adult Intelligence Scale （WAIS） and Wechsler Memory Scale（WMS） in 53 male oatients with alcohol dependence and 34 matched healthy controls, inter-group difference was compared and correlation analyses were conducted for risk factors of cognitive impairment in the patients. Results Intelligent quotient（IQ,86. 03±9. 87） and memory quotient（MQ, 61.07±10.13） were significantly lower in the patients than in the controls（P〈0.01） ; each factor score of both the WAIS and WMS was lower in the patients than in the controls（P〈0.05 or 0.01）. Correlation analyses showed that the IQ and MQ of the patients were negativelt related to the time of drinking wine（P〈 0.01） and positively to educational levels and onset age of customary drinking（P〈0.05）. Conclusion Patients with chronic alcohol dependence has notably cognitive impairment.