慢性乙型肝炎磁共振扩散成像与病情程度的关系

Relationship of magnetic resonance diffusion weighted imaging to histology in the patient of chronic type B hepatitis

目的探讨慢性乙型肝炎磁共振弥散成像与肝炎严重程度之间的相关性,评价磁共振弥散成像在慢乙肝中的应用价值。方法30例行肝穿刺活检的慢性乙型肝炎患者和10例健康志愿者在1.5 T磁共振设备上行弥散成像,测表观弥散系数(ADC)值,弥散敏感系数b值取50、100、300及500、700 s/mm2。30例患者病理结果按Knodell HAI积分系统分级,比较各级的ADC值。结果不同分度的慢性乙型肝炎ADC值之间有一定的差异。b值选700 s/mm2时,肝脏纤维化患者和无纤维化者ADC值差异有统计学意义,炎症积分和纤维化积分低级别和高级别间ADC值差异也有统计学意义。结论磁共振弥散成像是一种有价值的慢性乙型肝炎分级的诊断方法。

Objective To investigate the relationship between magnetic resonance diffusion weighted imaging（DWI） and severity of chronic viral hepatitis. Methods Thirty patients of chronic viral hepatitis who received liver biopsy and 10 healthy volunteers were included in this study. All of them underwent DWI on a 1.5T MRI device. Apparent diffusion coefficient （ADC） of the liver were measured respectively when b value were set as 50, 100, 300, 500 and 700 s/mm^2. Biopsy specimens were scored for fibrosis and necroinflammation according to the Knodell histology activity index （HAI）. Resalts When b value was set as 700 s/mm^2 , statistical difference was showed between the fibrosis group and the non fibrosis group, statistical difference was also shown among the different degrees of necroinflammation and fibrosis. Conclusion DWI is a valuable method for grading and staging of chronic viral hepatitis.