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丹参酮微乳的制备及大鼠在体肠吸收 被引量:13

Preparation of tanshinone microemulsion and its absorption in rat intestine in situ
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摘要 目的:制备丹参酮微乳(Tan-ME),并考察其性质及大鼠在体肠吸收特性。方法:Zetapals多功能电位/粒度分析仪测定Tan-ME的粒度及其分布,原子力显徽镜观察微乳粒子形态。建立测定肠回流液中丹参酮Ⅱ_A的HPLC测定方法。结果:Tan-ME乳滴平均粒径为(32.25±6.59)nm,粒度均匀。肠吸收实验结果表明,Tan-ME能促进丹参酮在大鼠小肠的吸收,但Tan-ME吸收速率受Tan-ME水相含量影响较大。结论:Tan-ME制剂能够促进丹参酮在大鼠小肠的吸收,提高丹参酮的生物利用度。 Objective: To prepare tanshinone microemulsion (Tan-ME) and investigate its properities and the absorption character in rat intestine in situ. Method: The microemulsions were prepared and characterized using Zetapals Zeta potential/particle size analysis and atomic force microscope. A HPLC method for determination of tanshinone Ⅱ A in the intestinal flux was established. Resuit: The Tan-ME was fine droplet with an average droplet size of (32. 25 ±6. 59) nm. The results of Tan-ME absorption in small intestinal indicated that Tan-ME could improve the absorption of tanshinone Ⅱ A in rat small intestine, but the absorption coefficient of Tan-ME, Ka was influenced by the ratio of water-phase in Tan-ME. Conclusion: Tan-ME could improve the absorption of tanshinone Ⅱ A in rat small intestine. Thus bioavailability of tanshinone was improved.
出处 《中国中药杂志》 CAS CSCD 北大核心 2007年第11期1024-1027,共4页 China Journal of Chinese Materia Medica
关键词 丹参酮 微乳 肠吸收 microemulsion tanshinone Ⅱ A intestinal absorption
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