刺状鱼栖苔化学成分研究

Studies on chemical constitutes of Acantophora spicifera

目的:研究红藻刺状鱼栖苔Acantophora spicifera化学成分。方法:利用正相和反相色谱,Sephadex LH-20色谱以及反相HPLC等手段进行分离纯化,应用MS,IR和ID,2D-NMR等方法鉴定结构。结果:从穗状鱼栖苔中分离鉴定了6个化合物,分别为aplysin(1),loloilide(2),(R)-(-)-dehydrovomifoliol(3),尿嘧啶(4),胸腺嘧啶(5),1-methoxy-4-(1-propenyl)benzene(6)。结论:所有化合物均为首次从本属海藻中分离得到,其中化合物6为首次从海洋生物中分离得到。

Objective： To study the chemical constitutes ofAcantophora spicifera. Method： Compounds were isolated by normal phase silica gel and Sephadex LH -20 gel column chromatography, and reverse-phase HPLC, as well as recrystallization. Their structures were elucidated by spectroscopic methods. Result： Seven compounds were isolated from A. spicifera and their structures were identified as aplysin （1）, loloilide （2）, （R）-（ -）-dehydrovomifoliol （3）, uracil （4）, thymine （5）, 1-methoxy-4-（1-propenyl） benzene （6）. Conclusion： The compounds were obtained from this genus for the first time. Compound 6 was firstly obtained from marine organisms.