摘要
目的:研究产自山西的狭苞橐吾Ligularia intermedia的化学成分。方法:用硅胶柱色谱(CC)、制备薄层色谱(PTLC)、重结晶等方法进行分离纯化,经现代波谱技术:红外、质谱、一维和二维核磁共振谱及X-射线单晶衍射等方法对化合物进行结构鉴定。结果:分离鉴定了9个化合物,分别为:8β-hydroxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(1),8β-methoxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(2),蜂斗菜素(petasin,3)。异蜂斗菜素(isopetasin,4),liguhodgsonal(S),ligudentatol(6),ligujapone(7)。羽扇豆醇(lupeol,8)和羽扇豆醇棕榈酸酯(lupeol palmitate,9)。结论:其中化合物2,3,4,6,7,9为首次从狭苞橐吾中获得。
Objective: To study the chemical constituents of Ligularia intermedia of Shanxi. Method: The compounds were isolated by column chromatography on silica gel and preparative TLC. The structures were identified by IR, MS, 1D/2DNMR spectral data and X-ray single crystal diffraction and other methodsl. Result: Nine compound were isolated and identified as 8β-hydroxyeremophil-7 ( 1 1 ) -ene-12, 8 α (4β, 6α) -diolide ( 1 ), 8β-methoxyeremophil-7 ( 11 ) -ene-12, 8α (4β, 6α) -diolide (2), petasin (3), isopetasin (4), liguhodgsonal (5), ligudentatol (6), ligujapone (7), lupeol (8) and lupeol palmitate (9). Conclusion: Compounds 2, 3, 4, 6, 7 and 9 were isolated from the plant for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第11期1044-1047,共4页
China Journal of Chinese Materia Medica
关键词
狭苞橐吾
化学成分
倍半萜
Ligularia intermedia
chemical constituents
sesquiterpenes