摘要
感音神经性耳聋是耳鼻咽喉科的常见病、多发病之一,严重影响人类的健康和生活质量。本文从毛细胞的再生,内耳的解剖特点,神经营养因子作用及其借助于载体在内耳表达状况,基因导入途径等几方面探讨基因治疗的可行性及发展方向。
出处
《国际耳鼻咽喉头颈外科杂志》
2007年第1期54-57,共4页
International Journal of Otolaryngology-Head and Neck Surgery
参考文献20
-
1Morsli H,Choo D,Ryan A,et al.Development of the mouse inner ear and origin of its sensory organs.J Neurosci,1998,18(9):3327-3335.
-
2Lidshitz J,Furman AC,Altman KW,et al.Spatial tuning curves along the chick basilar papilla in normal and sound-exposed ears.J Assoc Res Otolaryngol,2004,5(2):171-184.
-
3Stone JS,Choi YS,Woolley SM,et al.Progenitor cell cycling during hair cell regeneration in the vestibular and auditory epithelia of the chick.J Neurocytol,1999,28(10-11):863-876.
-
4Berggren D,Liu W,Frenz D,et al.Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants.Hear Res,2003,180(1-2):114-125.
-
5Zheng J,Gao WQ.Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears.Nat Neurosci,2000,3(6):580-586.
-
6Shou J,Zheng J,Gao WQ.Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hathl.Mol Cell Neurosci,2003,23 (2):169-179.
-
7Emfors P,Van de Water TR,Loring J,et al.Complementary role of BDNF and NT-3 in vestibular and auditory development.Neuron,1995,14(6):1153-1164.
-
8Dejda A,Sokolowska P,Nowak JZ et al.Neuroprotective potential of three neuropeptides PACAP,VIP and PHI.Pharmacological Rep,2005,57(3):307-320.
-
9Raphael Y,Frisancho JC,Roessler BJ.Adenoviral-mediated genetransfer into guinea pig cochlear cells in vivo.Neurosci Lett,1996,207(2):137-141.
-
10Duan ML,Bordet T,Mezzina M,et al.Adenoviral and adeno-associated viral vector mediated gene transfer in the guinea pig cochlea.Neuroreport,2002,13(10):1295-1299.
同被引文献9
-
1胡岢.老年性耳聋的研究进展[J].中国听力语言康复科学杂志,2005,34(2):8-11. 被引量：34
-
2谢静,龚树生.衰老与老年性耳聋[J].国际耳鼻咽喉头颈外科杂志,2006,30(6):367-370. 被引量：8
-
3王君玉,廖建春,胡国汉,施小恬,党瑞山,刘环海,姚琪.经乳突乙状窦入路手术及其相关的应用解剖[J].解剖与临床,2007,12(2):79-81. 被引量：15
-
4Xia Z, Dickens M, Raingeand J, et al. Opposing effects of ERK and JNK- p38 MAP kinases on apoptosis. Science, 1995,270 : 1326-1331.
-
5Dajda A, Sokolouska P, Nonwak JZ, et al. Neuroprotective potontial of three europeptides PACAP, VIP and PHI. Pharmacological Rep,2005, 57:307-320.
-
6Shah SB, Gladstone HB, Willians H, et al. An extended study : protective effects of erve growth factor in neomycin-induced auditory neural degener- ation. Am J Otol,2001,16:310-314.
-
7杨晓琦,余力生,马鑫.耳后注射复方倍他米松治疗顽固性低频型感音神经性聋[J].中华耳鼻咽喉头颈外科杂志,2007,42(11):814-816. 被引量：87
-
8刘辉,余力生,汪贺媛.神经生长因子对拟老化豚鼠听功能的保护[J].中国耳鼻咽喉头颈外科,2008,15(4):175-177. 被引量：7
-
9静媛媛,余力生,李兴启.耳后注射复方倍他米松豚鼠血浆中药代动力学特征[J].听力学及言语疾病杂志,2009,17(4):354-357. 被引量：69
二级引证文献5
-
1何丽,李健鹰,刘辉,蔡丽.老年性耳聋患者心理反应及护理干预[J].临床合理用药杂志,2012,5(8):165-166. 被引量：3
-
2刘卫红,姚琦,王陈荣,王瑛,陈望燕.葛根素注射液耳后注射联合声频共振治疗老年性聋疗效观察[J].新中医,2013,45(3):110-113. 被引量：5
-
3周雅婷,何扬子,邝文辉.感音神经性耳聋的治疗研究进展[J].按摩与康复医学,2015,6(24):23-24. 被引量：1
-
4刘根久,李随勤.声频共振治疗神经性耳聋的效果观察[J].西南国防医药,2016,26(9):1047-1049. 被引量：5
-
5陈爱平,王海波.耳后注射糖皮质激素治疗突发性聋的研究进展[J].临床耳鼻咽喉头颈外科杂志,2016,30(19):1572-1575. 被引量：21
-
1王俊,王士礼.感音神经性聋基因治疗[J].国际耳鼻咽喉头颈外科杂志,2006,30(6):385-388.
-
2李潇.基因疗法使内耳生长出新的毛细胞[J].中国生物化学与分子生物学报,2003,19(6):750-750.
-
3王艳莉,郭玉芬,王秋菊.大前庭水管综合征相关基因研究进展[J].国际耳鼻咽喉头颈外科杂志,2011,35(4):187-190.
-
4基因疗法首次使哺乳动物耳中新长出听毛细胞[J].科技信息（山东）,2003(7):42-42.
-
5付勇,龚树生.神经干细胞耳蜗移植与感音神经性耳聋基因治疗[J].中国医学文摘（耳鼻咽喉科学）,2004,19(1):14-17.
-
6人类听力基因现身[J].基础医学与临床,2002,22(5):433-433.
-
7陈曦,李进让,孙建军.急性低频感音神经性聋[J].国际耳鼻咽喉头颈外科杂志,2011,35(4):212-214. 被引量：4
-
8杨阳,孔维佳.耳蜗疾病基因治疗载体[J].国际耳鼻咽喉头颈外科杂志,2008,32(4):213-216.
-
9聋哑病研究取得重大进展[J].吉林医学信息,1999,16(2):1-1.
-
10朱珠,郑国玺,祝康.Atoh1基因与内耳毛细胞再生[J].国际耳鼻咽喉头颈外科杂志,2010,34(6):311-314.
