正常中国汉人及精神分裂症患者红细胞COMT活性分析

Erythrocytes catechol-O-methyltransferase activity in normal Chinese Han people and patients with schizophrenia

目的:分析红细胞COMT活性与精神分裂症的关系,探讨精神分裂症发病的生化机制。方法:采用高效液相色谱法测定112例精神分裂症患者和116例健康正常人红细胞中COMT的活性,用SPSS统计软件对测定结果进行检验比较。结果:患者组与对照组年龄差异无显著性(P>0.05),患者组男女之间、对照组男女之间COMT活性差异也无显著性(P>0.05),COMT活性频率分布患者组在4.5～26.3nmol/ml RBC/hr范围,对照组为7.2～28.3 nmol/ml RBC/hr范围。患者组COMT平均活性为(12.2±4.0)nmol/ml RBC/hr,对照组COMT平均活性为(16.6±3.7)nmol/ml RBC/hr。男性患者为(12.3±3.8)nmol/ml RBC/hr,女性患者为(11.6±4.0)nmol/ml RBC/hr,对照组男性为(16.5±4.5)nmol/ml RBC/hr,女性为(15.3±3.9)nmol/ml RBC/hr,患者组和对照组及男、女性患者和男、女性对照者之间,COMT活性的差异均具非常显著性(P<0.001)。结论:精神分裂症患者红细胞COMT活性显著低于正常人,提示低活性COMT基因与精神分裂症关联。

Objective：To analyze the relationship between catechol - O - methyltransferase （COMT） activity and schizophrenia. To explore the biological mechanism of the etiology of schizophrenia. Methods：The activities of 112 schizophrenia and 116 normal control were measured with high performance liquid chromatography, all examined data were tested by SPSS 11.0v. Results ： There was no significant difference between patients group and control group in sex and age （ p 〉 0.05 ）, and no difference between male and female group in COMT activity. COMT activity frequency distribution of patients group and control group are at the range of 4.5. - 26. 3nmol/ml RBC/hr and 7.2 -28.3nmol/ml RBC/hr separately. The average activity of COMT in patients group and control group were 12.20 ± 4.0nmol/ml RBC/hr and 16.6 ± 3.7nmol/ml RBC/hr representatively. COMT activity in male and female patient were 12.3 ± 3.8nmol/ml RBC/hr and 11.6 ± 4.0nmol/ml RBC/hr. , male and female control group were 16.5 ± 4.5nmol/ml RBC/hr and 15.3 ±3.9nmol/ml RBC/hr, there were significant difference between patients group and control group and also between male and female （P 〈0. 001 ）. Conclusions： The activity of COMT in affective disorders red cells is lower than normal population and suggested that the lower COMT activity of erythrocytes associated with schizophrenia.