西酞普兰与阿米替林治疗老年抑郁症对照研究

A controlled study on the treatment of senile depression with Citalopram and amitriptyline

目的:探讨西酞普兰与阿米替林治疗老年抑郁症的疗效及不良反应。方法:将96例老年抑郁症患者采用随机分组的方法,分为西酞普兰组和阿米替林组,治疗8周采用4级临床疗效及汉密尔顿抑郁量表(HAMA)、汉密尔顿焦虑量表(HAMD)、副反应量表(TESS)评定疗效和不良反应。结果:西酞普兰与阿米替林抗抑郁的疗效相似(P>0.05),抗焦虑效果优于阿米替林,而且不良反应更轻(P<0.05)。结论:西酞普兰是一种既有效又安全的新型抗抑郁药,适合对老年抑郁症的治疗。

Objective：To explore the efficacy and side effects of Citalopram and amitriptyline. Methods：96 elderly depressive patients who met CCMD - 3 criterion for depression episode were randomly assigned to Citalopram group （ n = 48 ） and amitriptyline group （n = 48 ） for the treatment of 8 weeks. The clinical efficacy was evaluated by HAMD and HAMA. The side effects were evaluated by TESS. Results： There was no significant difference of the efficacy between two groups（ P 〉 0.05 ）. Citalopram showed rapider efficacy and less side effects than amitriptyline （ P 〈 0.05 ）. Conclusions： Citalopram showed observably rapider efficacy in reducing depression and anxiety symptoms and less side effects in treating elderly depression.