达体朗与国产氟西汀片治疗抑郁症对照研究

A control study of tianeptine and fluoxetine in the treatment of depression

目的:比较达体朗与国产氟西汀片的抗抑郁效果及不良反应。方法:随机将60例符合CCMD-3情感性精神障碍(抑郁发作)诊断标准的患者分为达体朗组(30例)和氟西汀组(30例)。疗程6周,在0、1、2、4、6周评定汉密尔顿抑郁量表(HAMD,17项),并评定疗效、记录出现的不良反应。结果:达体朗从疗后第2周HAMD评分才开始显著下降,而氟西汀从疗后第1周HAMD评分就开始显著下降了;但治疗6周后,达体朗的有效率(90.0%)和显效率(73.3%)与国产氟西汀片剂接近(分别为90.0%和80.0%)。2组患者的不良反应相似,差异无显著性(P>0.05)。结论:达体朗和氟西汀治疗抑郁症疗效相当,不良反应少。

Objective： To study the efficacy and safety of tianeptine and fluoxetine in the treatment of depression. Methods ：60 depressed patients were randomized into tianeptine group （ n = 30） and fluoxetine group （ n = 30）, and studied for 6 week. HAMD and self-edited scale were used to assess the efficacy and side effects before and 1st week, 2nd week, 4th week and 6th week after the treatment. Results： There was no significant difference in efficacy between the two groups. HAMD scores decreased dramatically lower in the tianeptine group than that in the fluoxetine group. The efficacy rate of tianeptine was 90.0%, in which 73.3% were improved markedly. The efficacy rate of quetiapine was 90.0% , in which 80.0% were improved markedly. There was no significantly difference in the side effects between two groups. Conclusions ： It is suggested that both drugs are effective exactly in the treatment of depressive patients. They had few side effects and can be a first drug choice.