万拉法新与帕罗西汀治疗抑郁症对照研究

Comparative study between venlafaxine and paroxetine in treatment of depression

目的:评价万拉法新治疗抑郁症的临床疗效和安全性。方法:将门诊和住院患者63例随机分为两组,分别给予万拉法新和帕罗西汀治疗,治疗6周。用汉密顿抑郁量表(HAMD)评定疗效,用抗抑郁药副反应量表(SERS)评定不良反应。结果:治疗6周时万拉法新组和帕罗西汀组的有效率分别为80.6%和74.2%,两者比较差异无显著性(P>0.05),但万拉法新组的痊愈率达到51.6%,和帕罗西汀组25.8%相比差异有显著性(P<0.05),同时万拉法新组的起效要比帕罗西汀组要快。两组不良反应均轻微。结论:万拉法新是一种安全有效的抗抑郁药,起效较快。

Objective：To evaluate the efficacy and side effect of venlafaxine in the treatment of depression. Methods ：63 out - patients and in - patients were divided into two groups, treated by venlafaxine and paroxetine respectively for 6 weeks. The efficacy was assessed by Hamilton depression rating scale （HAMD） and the safety was assessed by Rating Scale for Side Effects （SERS）. Results： After 6 weeks treatment, the efficacy rate of the venlafaxine group and paroxetine group were 80.6% and 74.2%, respectively. The results have no remarkable differences in two groups（P 〉0.05）. but venlafaxine group＇s convalescing rate achieved 51.6% and the paroxetine group 25.8%, The results have remarkable differences in two groups （ P 〈0.05）. And the paroxetine group took effect more quickly. Conclusions： Venlafaxine is a safe and effective antidepressant. It has faster efficacy.