喹硫平联合碳酸锂治疗躁狂症的临床对照研究

A case control study of quetiapine with lithium therapeutic mania

目的:比较喹硫平与氯氮平联合碳酸锂治疗躁狂症的疗效及安全性。方法:将符合CCMD-3诊断标准的60例躁狂症患者,随机分为两组,在使用碳酸锂的基础上分别合并喹硫平或氯氮平进行为期6周的治疗,用BRMS评定疗效,用TESS评定不良反应。结果:喹硫平组与氯氮平组治疗躁狂症状均有显著性改善,有效率分别是93.3%和90%,疗效相当。药物不良反应喹硫平组显著少于氯氮平组。结论:喹硫平合并碳酸锂治疗躁狂症安全有效,依从性好。

Objective：To compare the therapeutic effects and safety between admininstration of clozapine with lithium carbonate and administration of quetiapine with lithium carbonate for treating mania. Methods：60 patients diagnosed as mania according to CCMD - 3 were randomly divided into two groups, one group receiving 6 weeks of administration of quetiapine with lithium carbonate （ quetiapine group） and the other receiving 6 weeks of administration of clozapine with lithium carbonate （ clozapine group）. The therapeutic effects were evaluated by BRMS and side effects were evaluated by TESS. Results： Both quetiapine group and clozapine group showed significant and similar improvement in symptoms of mania, with effective rate of 93.3% for the former and 90% for the latter. But, quetiapine group showed significantly lower scores of side effects by TESS than did clozapine group. Conclusions： administration of quetiapine with lithium carbonate can be effective and safe in treatment of mania, which may possess beneficial compliance with mania patients.