食管癌内分泌疗法可行性的探讨

A Study on the Feasibility of Sex Hormone Treatment for Esophageal Carcinoma

为探讨食管癌的发生、发展与性激素及其受体的关系，及内分泌治疗的可能性。采用放射配体结合分析法定量测定２７例原发性食管癌病人的癌组织、正常食管粘膜组织及外周血白细胞中的雌激素受体（ＥＲ）和雄激素受体（ＡＲ）的含量；同时应用放免法测定病人血浆中雌二醇（Ｅ２）和睾酮（Ｔ）的水平。结果见食管癌组织中存在ＥＲ和ＡＲ，受体含量显著高于正常对照组，且与病人性别及鳞癌病理分级有显著关系。外周血白细胞中ＥＲ和ＡＲ的含量明显降低。血浆中Ｅ２和Ｔ水平均在正常值范围内。研究提示，性激素及其受体在食管癌的发生、发展中起着一定的作用，并对今后在食管癌的临床治疗中，提出内分泌疗法的可行性设想。

To investigate the relationship between the development of esophageal malignancy and sex hormones and their receptors in order to assess the feasibility of endocrinotherapy for cancer of esophagus.Methods:Estrogen receptors (ER) and androgen receptors (AR) in the cancer specimens,normal esophageal mucosa and peripheral blood leucocytes were quantitatively measured by the radio-ligand assay method in 27 cases of primary esophageal carcinoma.In the meantime,levels of estradiol (Ez) and testosterone (T) in patients' plasma were determined using radioimmunoassay method.Results:The contents of ER and AR in esophageal carcinoma tissues were significantly higher than in those of normal esophageal mucosa (p<0.01) and were obviously related to the sex of patients (p<0.01) and pathological classifications of cancer (p<0.05).The contents of ER and AR in peripheral blood leucocytes markedly decreased (<100 specific binding sites/per cell).Both E 2 and T levels in plasma were within the normal range.Conclusion:It was indicated sex hormones and their receptors might play a certain role in the development of esophageal carcinoma,and endocrinotherapy might be feasible in the future clinical treatment.