c-Met及MMP-2在子宫内膜异位症在位子宫内膜的表达及意义

Expression and significance of c-Met and MMP-2 in the eutopic endometrium of endometriosis

目的探讨肝细胞生长因子受体(c-Met)及基质金属蛋白酶-2(MMP-2)与子宫内膜异位症发病机制的关系及临床意义。方法采用链霉素抗生物素蛋白-过氧化物酶(S-P)法检测45例盆腔子宫内膜异位症患者(内异症组)及30例非子宫内膜异位症妇女(对照组)的在位子宫内膜的c-Met与MMP-2的免疫表达水平。结果①盆腔子宫内膜异位症妇女的在位子宫内膜c-Met、MMP-2表达水平分别高于对照组(P均<0.01);②c-Met与MMP-2在两组中均呈正相关(对照组r=0.937,内异症组r=0.885)。结论类似肿瘤的转移和侵袭机制,c-Met、MMP-2在内异症的发病中发挥了重要作用。

Objective To explore the expression of c - Met and MMP - 2 in the eutopic endometrium of endometriosis and the relationship between c - Met and MMP - 2 in the pathogenesis of endometriosis. Methods Used the streptavidin - peroxi- dase（ S -P） immunohistochemical method to detect the expression of c -Met and MMP-2 in the eutopic endometrium of forty - five women with pelvic endometriosis and thirty women without endometriosis. Results ①The expression of c - Met and MMP - 2 were markedly higher in the eutopic endometrium of patients with pelvic endometriosis than that of controls（ P 〈 0.01 ）. ②We also observed a positive correlation between the expression of c - Met and MMP - 2 （ control r= 0. 937, endometriosis r = 0.885 ）. Conclusion Analogous to tumour metastasis and invasive mechanism, c - Met and MMP - 2 may play an important role in the pathogenesis of endometriosis.