吉西他滨 奥沙利铂治疗非小细胞肺癌

Gemcitabine Ccombined with Oxaliplatin in Treatment of Patients with Advanced Non-small Cell Lung Cancer

目的 评价吉西他滨联合奥沙利铂和吉西他滨联合顺铂治疗晚期非小细胞肺癌的近期疗效与不良反应。方法 40例非小细胞肺癌患者随机分组采用吉西他滨联合奥沙利铂（简称GO方案组和吉西他滨联合顺铂（简称GP方案组）方案治疗晚期非小细胞肺癌患者,21-28d为一个周期,完成3个周期治疗后评价疗效并观察不良反应。结果 GO方案组20例,CR1例,PR8例,有效率为45%;GP方案组20例,CR1例,PR7例,有效率为40%（P〉0.05）。两组不良反应比较：白细胞减少、血小板减少等不良反应相似;GO组脱发、胃肠道反应较GP组减少（P〈0.05）。结论 两方案治疗晚期非小细胞肺癌近期疗效相近;白细胞下降、血小板减少等毒副反应相似,而胃肠道反应、脱发等不良反应差别有统计学意义,但均可耐受。

Objective To evaluate the recent efficacy and side effects of oxaliplatin （OXA） in combination with gemcitabine （GEM） or DDP in combination with GEM in the treatment of advanced non - small cell lung cancer （ NSCLC ）. Methods 40 patients with NSCLC were randomly treated by OXA and GEM （ GO regimen） or DDP and GEM （ GP group） regimen, repeated every 21 to 28 days. They received at least 3 cycles of chemotherapy. Results There were 20 patients treated with GO regimen,in which there were 1 complete response （CR） patients, 8 patients showed partial response （PR） ,and the response rate （RR） was 45%. There were 20 patients treated with GP regimen. One patient showed CR, 7 patients showed PR, and the RR was 40%. There was no significant difference in RR between the two groups （ P 〉 0. 05）. The major toxicities, including leukopenia and phlebitis were similar between two groups. The incidences of gastrointestinal reaction and alopecia of GP regimen were more severe than those of GO regimen （ P 〈 0. 05）, but neuron toxicity of GO regimen was more obvious than that of GP regimen （ P 〈 0. 05）. Conclusion The efficacy of the two regimens is similar in the treatment of advanced NSCLC. The side effects such as leukopenia＇ and thrombocytopenia are similar in the two groups. But there are significant differences in gastrointestinal reaction and alopecia between the two groups. All the toxicities are well tolerable.