神经外科围手术期抗菌药物应用对照研究

Antibiotics Use During Perioperative Period in Neurosurgery:Case-control Study

目的了解实施《抗菌药物应用基本原则》后神经外科围手术期抗菌药物应用情况。方法应用抗菌药物使用调查表,对神经外科2005年81例手术患者和2006年83例手术患者抗菌药物使用情况进行比较调查。结果神经外科2005、2006年预防性应用抗菌药物使用率分别为87.7%、91.6%(P>0.05);术前使用率分别为8.6%、65.1%(P<0.05);平均用药时间分别为12.44、5.87 d(P<0.05);药敏实验率分别为9.9%、7.2%(P>0.05);给药途径均以静脉为主;给药频次符合《抗菌药物应用基本原则》;抗菌药物联合以单一使用为主。结论实施《抗菌药物应用基本原则》后,抗菌药物的合理应用逐步规范,但仍有不足之处需要多方面共同管理和改进。

OBJECTIVE To investigate the antibiotic use during perioperative period in neurosurgery ward after the implementation of Antibiotic Drug Use Guideline. METItODS By using self-designed questionnaires 81 outpatient cases in 2005 and 83 cases in 2006 during perioperative period in neurosurgery were surveyed. RESULTS The preventive use rate of antibiotic drug in neurosurgery in 2005 and 2006 were respectively 87. 7% and 91. 6% （P〈0.05） ; the preoperative use rate was 8.6%~ and 65.1% （P〈0.05） ; the mean time of using antibiotic drug was 12.44 days and 5. 87 days （P（0.05）; and the check rate of resistance of drugs was 9. 9% and 7. 2% （P〉0.05） ; both groups used drug mainly in vein and in single mode. CONCLUSIONS After the implementation of the Guideline the rational use of antibiotics is improved but there are some problems needed to manage further.