老年住院患者尿路感染病原菌的构成与耐药分析

Pathogens Isolated from Geriatric Inpatients with Urinary Tract Infections:Their Composition and Drug Resistance Analysis

目的分析老年住院患者尿培养病原菌的构成与耐药特性。方法对2003-2005年老年住院患者尿培养的病原菌,经VITEK AMS-60全自动微生物鉴定与药敏系统鉴定及药敏试验。结果老年住院患者医院内尿路感染仍以革兰阴性杆菌为主(72.9%),其他为革兰阳性球菌(14.3%)、真菌(12.8%);革兰阴性杆菌以大肠埃希菌为主(46.6%),革兰阳性球菌以粪肠球菌(5.3%)和凝固酶阴性葡萄球菌(4.9%)为主,真菌以白色假丝酵母菌为主(7.9%),3年间主要病原菌对常用抗菌药物的耐药率呈上升趋势。结论老年住院患者尿路感染的病原菌仍以大肠埃希菌为主,但多重耐药的细菌及真菌的分离率呈上升趋势。

OBJECTIVE To retrospectively analyze the results of the composition and drug resistance of urinary pathogens isolated from geriatric inpatients from 2003 to 2005. METHODS The identification and antibacterial drug sensitivity test of urinary pathogens was carried out by VITEK AMS-60. RESULTS Urinary tract infections of geriatric inpatients were still mostly caused by Gram-negative bacilli （72.9%）, others as Gram-positive cocci （14.3%） and fungi （12. 8%）. The majority of Gram-negative bacilli was Escherichia coli （46. 6%） and the majority of fungi was Candida albicans （7.9 %）, as for Gram-positive cocci, were Enterococcus faecalis （5.3 %） and coagulase negative Staphylococcus （4.9 %）. Drug resistance rate of common antibiotic against the majority of urinary pathogens showed an ascending trend. CONCLUSIONS E. coli is still the primary urinary pathogen among geriatric inpatients, but the isolation of fungi and multi-drug-resistant bacteria is on the rise.