鄂西山区尿路感染病原菌体外耐药性监测

Drug Resistance Supervision to Pathogens from Urinary Tract in Mountain Area of Western Hubei Province

目的了解鄂西山区尿路感染病原菌的分布及耐药现状,为指导临床合理使用抗菌药物提供依据。方法对2002-2005年389株尿路感染病原菌进行鉴定和体外耐药性监测。结果病原菌中大肠埃希菌居首位,占66.1%;尿路感染病原菌对亚胺培南和万古霉素耐药率均为0;产超广谱β-内酰胺酶(ESBLs)大肠埃希菌和肺炎克雷伯菌检出率分别为23.7%和25.9%。结论鄂西山区尿路感染病原菌,对常用抗菌药物耐药率总体低于湖北省平原地区同等级医院。

OBJECTIVE To investigate the distribution and drug resistance status to pathogens from urinary tract and offer scientific evidence for reasonable usage of antibiotics. METHODS Totally 389 isolates derived from infected urinary tract in mountain area of western Hubei Province from 2002 to 2005 were identified and antibiotic susceptibility test was performed. RESULTS Escherichia coli accounted for 66.10% ranking the first. The isolates were all susceptible to imipenem and vancomycin. The ratio of ESBLs in E. coli and Klebsiella pneumoniae was 23.7% and 25.9%, respectively. CONCLUSIONS The drug resistance rate in isolates derived from infected urinary tract of patients in mountain area was lower than in plain region of Hubei Province.