颈动脉硬化闭塞症的超声造影研究

Application study of ultrasound contrast agent in evaluating the carotid atherosclerosis oblitration

目的 探讨超声造影检查在颈部动脉硬化中应用的可行性。方法 应用超声造影观察36例颈部动脉粥样硬化患者造影前、后动脉斑块数量、形态特征等。应用彩色多普勒超声（CDFI）、超声造影检查测量动脉狭窄率；并与数字减影血管造影（DSA）作对照。结果 超声造影检查可发现更多造影前未发现的动脉斑块，清晰显示动脉内-中膜厚度，勾勒出动脉斑块大小及形态。与DSA对照，应用CDFI、超声造影诊断动脉粥样硬化所致颈部动脉闭塞的敏感性分别为55．6％、55．6％，特异性分别为84．2％、94．7％，准确率分别为75．0％、82．0％。结论 超声造影检查为颈部血管疾病的诊断提供了一种安全、有效、无创的诊断方法。

Objective To investigate the feasibility of intravenous contrast sonography in the diagnosis of carotid atherosclerosis. Methods Thirty-six cases with carotid stenosis were investigated,including the number and morphology and structure of plaques before and after injection of contrast agents. At the same time, ratio of stenosis was calculated and compared with digital subtraction angiography（DSA）. Results More plaques could be found and the intima-media thickness（IMT） would more clear after injection of the contrast agent. At the same time,the morphology and structure of plaques could be observed by using contrast agents. Compared with DSA, color Doppler flow imaging （CDFI） and contrast-enhanced ultrasound in detecting occlusion of carotid artery, subcalvian artery and vertebral artery,the sensitivity was 55.6% ,55.6% ,the specificity was 84. 2%,94.7% and the accuarcy was 75.0%, 82. 0%, respectively. Conclusions Contrast-enhanced ultrasonography is a safety, efficiently and non-invasive technique in diagnosis of carotid artery disease.