颌骨恶性纤维组织细胞瘤临床病理研究及电镜观察

Pathologic and Electron Microscopic Study of Maxillar Malignant Fibrous Histocytoma

本研究对8例颌骨恶性纤维组织细胞瘤进行了临床病理分析.光镜及电镜观察显示:颌骨MFH的病理改变与长骨发病者一致.瘤体成份为:瘤变的组织细胞、成纤维细胞样细胞、未分化细胞,可见典型的车辐或漩涡样结构.细胞间有较多微丝束分布.免疫组化染色:LYS阳性8例,在分化较好的瘤变组织细胞反应较强;AAT阳性5例,在分化差的组织细胞阳性反应强.本组观察提示:颌骨MFH应以手术治疗为主,对术后或晚期、复发患者予以适当化疗可缓解病情、延长生存时间.

Eight cases of MFH in maxilla were clinically analyzed and studied using optical and electron microscope, which showed that the pathologic changes of maxillar MFH was correspondent with those of long bone. Immunohistochemistry stain indicated that LYS was positive in 8 cases and AAA positive in 5 cases. The treatment of maxillar MFH mainly relys on operation. Chemotherapy coluld be used in postoperatve patients and advanced and recurrent lesions.