低氧对雄性高原鼠兔性腺的影响

EFFECT OF HYPOXIA ON THE SEX GLAND OF MALE PLATEAU PIKA

在人工模拟低氧环境下（低压舱模拟５０００ｍ和７０００ｍ海拔高度），低氧暴露２４ｈ和７ｄ，观察低氧对受试动物性腺的影响。结果表明，急性低氧２４ｈ，高原鼠兔血浆雌二醇（Ｅ２）明显升高；低氧暴露７ｄ，高原鼠兔血浆Ｅ２仍维持一较高水平；５０００ｍ低氧暴露７ｄ，其睾丸指数无明显变化，７０００ｍ时却有所降低。同等条件下，大鼠睾丸指数明显增高；５０００ｍ和７０００ｍ低氧暴露７ｄ对高原鼠兔睾丸组织形态无明显影响，然而，大鼠曲细精管间隙增大，且曲细精管内各级细胞排列紊乱。低氧环境下，高原鼠兔雄体血浆Ｅ２增高。

Effects of hypoxia on the sex gland of male plateau pika (Ochotona curzoniae) and rat were carried out by simulated different altitude (5 000 m and 7 000 m) in the well ventilated hypobaric pressure chamber for 24 h and 7 d, comparing with that at 2 300 m of altitude.The experiment shows: the plasma estrogen(E 2) level of male plateau pika increased obviously at 5 000 m and 7 000 m altitude for 24 h and 7 d. The ratio of testis to body weights in plateau pika was no change at 5 000 m of altitude but decreased at 7 000 m for hypoxia 7 d, by contrary, that of rat increased significantly at the same condition.The testicular histomorphology of plateau pika kept unchangeable at all altitude simulated for 7 d. These suggest that E 2 may play a role in an adaptation to hypoxia in Ochotona curzoniae .