摘要
目的:研究贝凡洛尔和美托洛尔对原发性高血压患者心率变异性的影响。方法:53例原发性高血压患者洗脱2周后,随机口服贝凡洛尔(n=26,贝凡洛尔组)100～200 mg/日,分两次口服,或美托洛尔(n=27,美托洛尔组)100～150 mg/日,分两次口服,治疗8周。服药前后行24小时动态心电图检查各1次,分析24小时时域和5分钟频域指标。结果:服药后贝凡洛尔组24小时长程时域指标:相邻RR间期之差的均方根(rMSSD),全部RR间期中相邻RR间期之差大于50 ms的心搏数除总的RR间期个数乘以100(PNN_(50))均较用药前增加,有显著性差异(P<0.05～0.01);5分钟短程频域指标:高频(HF)增加,低频(LF)/HF下降,与用药前比较有显著性差异(P<0.05)。而美托洛尔组24小时长程时域指标:rMSSD较用药前增加,有显著性差异(P<0.05),5分钟短程频域指标:HF较用药前增加,LF/AF则降低,均有显著性差异(P<0.05),组间比较无统计学差异。结论:与美托洛尔相比,具轻度α_1受体阻滞作用的高选择性β_1受体阻滞剂贝凡洛尔,同样改善原发性高血压患者的心率变异性。
Objective：To study the effects of bevantolol and metoprolol on heart rate variability （HRV）of primary hypertension patients.
Methods： After 2-week drug wash-out,53 patients with mild-to-moderate essential hypertension received bevantolol （n = 26） 100-200 mg per day, or metoprolol（ n = 27 ）100-150 mg per day for 8 weeks. The 24-hour ambulatory ECG was performed before and after 8 weeks treatment. The frequency domain of heart rate variability was analyzed.
Results： After 8 weeks treatment, rMSSD and PNN50 were increased. High-frequency （HF） was increased, Low Frequency （LF）, Very Low（VLF） and LF/HF were decreased. There were significant differences in rMSSD, PNN50, HF, LF/HF before and after active treatment. The result of bevantolol was similar to that of metoprolol （ P 〉 0. 05 ）.
Conclusion： Bevantolol,an α1 ＋ β1 blocker, shows the same beneficial effect on HRV as metoprolol in primary hypertension patients.
出处
《中国循环杂志》
CSCD
北大核心
2007年第2期118-120,共3页
Chinese Circulation Journal
