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Synthesis and Crystal Structure of 4-(4-Bromophenyl)- 3,4-dihydro-6-methyl quinolin-2(1H)-one

Synthesis and Crystal Structure of 4-(4-Bromophenyl)- 3,4-dihydro-6-methyl quinolin-2(1H)-one
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摘要 The title compound (C16H14BrNO) has been synthesized by the reaction of p-tolylamine, Meldrum’s acid and 4-bromo-benzaldehyde, and its structure was characterized by IR, 1H NMR and X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 7.6850(11), b = 8.3004(11), c = 21.301(3)A, β = 95.110(2)°, V = 1353.4(3) A^3, Mr = 316.19, Z = 4, Dc = 1.552 g/cm^3, μ(MoKα) = 3.028 mm-1, F(000) = 640, the final R = 0.0345 and wR = 0.0768. X-ray analysis reveals that the atoms of C(1), C(2), C(3), C(4), C(5) and N(1) form a six-membered ring of boat conformation. The title compound (C16H14BrNO) has been synthesized by the reaction of p-tolylamine, Meldrum’s acid and 4-bromo-benzaldehyde, and its structure was characterized by IR, 1H NMR and X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 7.6850(11), b = 8.3004(11), c = 21.301(3)A, β = 95.110(2)°, V = 1353.4(3) A^3, Mr = 316.19, Z = 4, Dc = 1.552 g/cm^3, μ(MoKα) = 3.028 mm-1, F(000) = 640, the final R = 0.0345 and wR = 0.0768. X-ray analysis reveals that the atoms of C(1), C(2), C(3), C(4), C(5) and N(1) form a six-membered ring of boat conformation.
出处 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第5期533-536,共4页 结构化学(英文)
基金 This work was supported by the National Natural Science Foundation of China (No. 20372057) Natural Science Foundation of Jiangsu Province (No. BK2006033) the Natural Science Foundation of Xuzhou Normal University (05XLA07)
关键词 QUINOLINE crystal structure quinoline, crystal structure
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  • 1Abd,E.; Hisham,A.Pharmazie.1997,52,28-32.
  • 2Sun,H.B.; Qing,F.L.; Chen,X.F.Synthesis 1997,1249-1251
  • 3Nevile,C.F.; Grundon,M.F.; Ramchandran,V.N.; Reisch,G.; Reisch,J.J.Chem.Soc.,Perkin Trans.1(9).1991,2261-2268.
  • 4Petal,M.; Mchugh,R.J.; Cordova,B.C.; Klabe,R.M.; Bacheler,L.T.; Erickson-Viitanen,S.; Rodgers,J.D.Bioorg.Med.Chem.Lett.2001,11,1943-1945.
  • 5Sharma,G.V.M.; Ilangovan,A.; Narayan,V.L.; Gurjar,M.K.Tetrahedron 2003,59,95-99.
  • 6Kuo,S.C.; Lee,H.; Juang,J.P.; Lin,Y.T.; Wu,T.S.; Chang,J.J.; Lendnicer,D.; Paull,K.D.; Lin,C.M.; Hamel,E.; Lee,K.H.J.Med.Chem.1993,36,1146-1156
  • 7Li,L.; Wang,H.K.; Kuo,S.C.; Wu,T.S.; Lendnicer,D.; Lin,C.M.; Hamel,E.; Lee.K.H.J.Med.Chem.1994,37,1126-1135.
  • 8Li,L.; Wang,H.K.; Kuo,S.C.; Wu,T.S.; Manger,A.; Lin,C.M.; Hamel,E.; Lee,K.H.J.Med.Chem.1994,37,3400-3407.
  • 9Zhang,S.H.; Feng,J.; Kuo,S.C.; Brossi,A.; Hamel,E.; Topsham,A.; Lee,K.H.J.Med.Chem.2000,43,167-176.
  • 10Sui,Z.; Nguyen,A.; Altom,J.; Fernandez,J.; Hilliard,J.J.; J Bernstein,I.; Barrett,J.F.; Ohemeng,K.A.Eur.J.Med.Chem.1999,42,381-387.

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