山东省医院感染监控网泌尿道感染病原菌及其耐药性分析

Bacterial Distribution and Antimicrobial Resistance of Urinary System Infection in Shangdong Province: Monitoring by Shandong Provincial Nosocomial Infection Surveillance System

目的了解山东省泌尿道医院感染病原菌及其耐药性变化趋势。方法统计分析山东省医院感染监控网2001年8月-2005年7月,泌尿道医院感染病原菌及其耐药情况。结果泌尿道医院感染共分离到病原菌933株,革兰阴性杆菌524株,占56.16%,革兰阳性菌214株,占22.94%,真菌195株,占20.90%;主要病原菌依次为大肠埃希菌(311株)、白色假丝酵母菌(74株)、肠球菌属(62株)等;药敏结果提示除真菌以外的大多数细菌出现多重耐药,革兰阴性菌对亚胺培南敏感,革兰阳性菌对万古霉素敏感。结论定期系统地进行细菌耐药监测,对临床合理用药具有重要的指导意义。

OBJECTIVE To observe bacterial distribution in urinary infection and trend of drug resistance in Shangdong Province. METHODS The patients with urinary infection monitored by Shandong Provincial Nosocomial Infection Surveillance System from Aug 2001 to Jul 2005 were analyzed and summarized. RESULTS Among 933 isolates, 524 strains （56.16~/00） were Gram-negative bacilli, 214（22.94%） were Gram-positive cocci and 195 （20.90%） fungi. The most common pathogens were Escherichia coli （311）, Candida albicans （74）, and Enterococcus spp （62）. Most of them were multidrug resistant. Most strains of Gram-negative bacilli were highly susceptible to imipenem, while most strains of Gram-positive cocci were highly susceptible to vancomycin. CONCLUSIONS Resistance detection of bacteria periodically has an important significance to clinical treatment with drugs.