单用左氧氟沙星与头孢呋辛联用阿奇霉素治疗社区获得性肺炎的对照研究

Comparison of Levofloxacin Alone and Cefuroxime Combined with Azithromycin for Patients with Community-acquired Pneumonia

目的比较左氧氟沙星与头孢呋辛联用阿奇霉素治疗社区获得性肺炎的临床疗效、细菌清除率和安全性。方法将55例社区获得性肺炎患者,随机分为左氧氟沙星治疗组和头孢呋辛联用阿奇霉素治疗组,观察两组患者的临床疗效、细菌清除率和不良反应。结果左氧氟沙星组30例患者,痊愈25例(83.3%),显效3例(10.0%),总有效率93.3%,细菌清除率85.7%,不良反应发生率3.3%;头孢呋辛联用阿奇霉素组25例患者,痊愈20例(80.0%),显效3例(12.0%),总有效率92.0%,细菌清除率88.9%,不良反应发生率4.0%。结论左氧氟沙星与头孢呋辛联用阿奇霉素治疗社区获得性肺炎的临床疗效、细菌清除率和安全性差异无统计学意义。

OBJECTIVE To evaluate the efficacy, the eradication rates of pathogens and safety of levofloxacin in patients with community-acquired pneumonia （CAP） in comparison with therapy using a combination of cefuroxime plus azithromycin. METHODS Fifty five patients with CAP were randomly divided into two groups： levofloxacin alone and cefuroxime plus azithromycin, and the efficacy, the eradication rates of pathogens and the rates of side effects were observed. RESULTS From 30 patients in the levofloxacin group, 25 patients （83.3%） were clinically cured and 3 patients （10. 0M） were improved. And from 25 patients in the cefuroxime plus azithromycin group, 20 patients （80. 0%） were clinically cured and 3 patients （12.0%） were improved. The eradication rates of pathogens were 85.7M and 88.9M, respectively. And the rates of side effects were 3.3% and 4.0%, respectively. CONCLUSIONS There are no significant differences in the efficacy, the eradication rates of pathogens and safety between 2 groups in treating community-acquired pneumonia.