缺血性脑卒中患者纤维蛋白原水平与颈动脉粥样硬化关系的研究

The research on the relationship of fibrinogen and carotid atherosclerosis in ischemic stroke patients

目的探讨缺血性脑卒中患者颈动脉粥样硬化与纤维蛋白原水平的关系。方法对缺血性脑卒中住院患者,应用颈部多普勒超声检测颈部血管内中膜厚度及斑块形成情况,并同期检测患者血浆纤维蛋白原浓度。结果125例患者40例发现有颈动脉粥样硬化病变,其中16例患者经超声检查诊断为颈动脉粥样硬化斑块,24例患者诊断为颈动脉内中膜增厚。有颈动脉粥样硬化病变的患者平均纤维蛋白原水平显著高于无颈动脉粥样硬化组患者(P<0.05),并且随着平均纤维蛋白原水平升高颈动脉粥样硬化病变的发生率升高。结论缺血性脑卒中患者颈动脉粥样硬化和纤维蛋白原水平之间有密切相关性。

Objective To evaluate the relationship of fibrinogen and carotid atherosclerosis in ischemic stroke patients. Methods The ischemic stroke patients underwent Doppler ultrasound examination to detect the intima-media thickness （IMT） and the plaque formation of the common carotid arteries. A blood sample was drawn to evaluate the concentration of fibrinogen. Results One hundred and twenty five ischemic stroke patients were included. There were 40 patients with carotid atherosclerosis, 16 patients with carotid atherosclerosis plaque and 24 patients with increased IMT. The average level of fibrinogen was significantly higher in patients with carotid atherosclerosis than those without carotid atherosclerosis （P 〈 0. 05 ）. The increase in the incidence of carotid atherosclerosis was associated with the increase in the plasma level of fibrinogen. Conclusion The results of this study showed that the high plasma level of fibrinogen is strongly associated with carotid atherosclerosis in ischemic stroke patients.