1,4,5-三磷酸肌醇受体与心血管疾病

The research of inositol 1,4,5-triphosphate receptor and cardiovascular disease

1,4,5-三磷酸肌醇受体是一种细胞内Ca2+释放通道,它与1,4,5-三磷酸肌醇结合后,引起Ca2+浓度发生改变,从而参与钙信号转导,调节多种细胞代谢活动。近年来,越来越多的研究提示其参与心力衰竭、心肌肥厚、心房颤动等心血管疾病的发生。现就三磷酸肌醇受体的结构、分布、激活Ca2+通道开放以及与心血管疾病发病机制的研究进展等作一综述。

Inositol 1,4,5-trisphosphate receptor （IP3 R） functions as an intracellular Ca^2＋ channel. It participates in the pathways of calcium-induced signal transduction and regulations of cellular activity through a change in intracellular Ca^2＋ concentration when binding to its ligand, inositol 1,4,5-trisphosphate （IP3 ）. In recent years, increasingly researches have shown that IP3 Rs played a vital role in the development of some cardiovascular disease, especially in heart failure, myocardial hypertrophy and atrial fibrillation. In this review, the recent advancement in structure and distribution of IP3 R, the mechanism it activates Ca^2＋ channel and its relationship with cardiovascular disease are discussed.