血红素加氧酶/一氧化碳在血管平滑肌细胞中的研究

Progress in experimental study of heme oxygenase/carbon monoxide pathway on vascular smooth muscle cells

血红素加氧酶是哺乳动物中血红素代谢的限速酶,它能分解血红素成胆绿素、一氧化碳和铁。其中血红素加氧酶-1又称诱导型血红素加氧酶,它在血管平滑肌细胞中表达,可以被诸多因素所诱导。由血红素加氧酶-1催化产生的一氧化碳是一种重要的内源性生物信使,目前研究已经表明了它在循环系统中的重要作用。血管平滑肌细胞的增殖和凋亡是众多的心血管疾病如高血压、动脉粥样硬化的病理基础。血红素加氧酶/一氧化碳系统与血管平滑肌细胞的增殖和凋亡有着密切的关系。目前研究发现不少心血管药物通过该系统影响平滑肌细胞的增殖和凋亡,为新药物的开发奠定了基础。

Heme oxygenase is the rate - limiting enzyme of heme metabolism, which catalyzes the degradation of heme to carbon monoxide （CO）, iron, and biliverdin. Heme oxygenase - 1, one of its isoenzymes, expressed in vascular smooth muscle cells（VSMCs） , can be induced by a variety of stresses. CO, as the degradation product of heme oxygenase, is a very important endogenous gas messenger. Recent studies have indica- ted its crucial role in cardiovascular system. The proliferation and apoptosis of VSMCs ,which are pathogensis of many cardiovascular diseases such as hypertension and artherosclerosis, are correlated with heme oxygenase/ carbon monoxide pathway. Recent researches confirmed that considerable medicines influenced proliferation and apoptosis of VSMCs through this way, which established a foundation for exploitation of new drugs.