抵抗素参与血管内皮细胞功能障碍的研究进展

The development of studies about resistin participation in endothelial dysfunction

抵抗素是脂肪细胞分泌的一种多肽类激素,早有研究证明抵抗素通过影响胰岛素信号转导参与了胰岛素抵抗,与2型糖尿病的发生发展密切相关。越来越多研究表明抵抗素可以促进肿瘤坏死因子α、白细胞介素6等炎症标志物的表达,诱导血管炎症反应的发生,从而损伤血管内皮细胞并影响其功能。内皮细胞功能异常又是动脉粥样硬化及糖尿病血管并发症病理过程的始动环节,提示抵抗素可能在心血管疾病的发生发展中起重要作用。本文就有关抵抗素参与血管内皮细胞功能障碍的研究进展作一综述。

Resistin is a poly-peptide hormone secreted by adipose cells. It has been proved that resistin participates in insulin resistance by affecting insulin signaling pathway and is closely related to pathogenesis of type 2 diabetes mellitus. More and more studies show that resistin can promote the expression of inflammatory markers such as TNF-α and IL-6, induce vascular inflammatory reaction, and damage blood vessel endothelium and affect its function. Endothelial dysfunction is a trigging step involved in pathological process of artherosclerosis and diatetic vascular complication, suggesting resistin maybe play an important role in the occurrence and develpment of cardiovascular diseases. In this article, we will summarize the studies about resistin participation in endothelial dysfunction.