支气管肺泡灌洗液、血清中铁蛋白、CA-199、CEA对肺癌的诊断价值

Value of determination of levels of SF,CA-199,CEA in bronchoalveolar lavage fluid and serum in the diagnosis of lung cancer

目的探讨支气管肺泡灌洗液(BALF)、血清中铁蛋白(SF)、糖链抗原199(CA-199)和癌胚抗原(CEA)测定对肺癌的诊断价值。方法采用免疫放射分析法(IRMA)测定60例肺癌患者和68例肺良性疾病患者BALF和血清中SF、CA-199、CEA的水平。结果肺癌组BALF和血清中SF、CA-199、CEA明显高于肺良性疾病组,有非常显著性差异(P<0.0001),肺癌组BALF的SF、CA-199、CEA水平高于血清,有显著性差异(P<0.001),肺癌组3项联合检测的敏感性及准确性明显高于单项检测(P<0.05)。结论联合检测BALF及血清中的SF、CA-199、CEA对于鉴别肺部良、恶性疾病有较好的临床价值,对肺癌的早期诊断提供良好手段。

Objective To explore the diagnostic value of lung cancer of serum ferritin （SF）, carbohydrate antigen （CA-199） and carcinoembryonic antigen （CEA） in bronchoalveolar lavage fluid （BALF） and serum. Methods Measures were made and analyzed on SF, CA-199, CEA in BALF and serum of 60 patients with lung cancers and 68 patients with benign lung diseases. Results Values of SF, CA-199, CEA in BALF and serum concentration in lung cancer was significantly higher than those in benign lung diseases （P 〈 0.001 ）. Values of SF, CA-199, CEA in BALF concentration were higher than the serum in lung cancer （ P 〈 0. 01 ）. The sensitivity and accuracy of combined measurement were obviously higher than those using single measurement （ P 〈 0. 05 ）. Conclusion Combined measurement of SF, CA-199, CEA in BALF and serum has a preferable clinical value in differential diagnosis of benign and malignant lung diseases. It provides useful information for early diagnosis of disease in patients with lung cancer.