摘要
目的探讨支气管肺泡灌洗液(BALF)、血清中铁蛋白(SF)、糖链抗原199(CA-199)和癌胚抗原(CEA)测定对肺癌的诊断价值。方法采用免疫放射分析法(IRMA)测定60例肺癌患者和68例肺良性疾病患者BALF和血清中SF、CA-199、CEA的水平。结果肺癌组BALF和血清中SF、CA-199、CEA明显高于肺良性疾病组,有非常显著性差异(P<0.0001),肺癌组BALF的SF、CA-199、CEA水平高于血清,有显著性差异(P<0.001),肺癌组3项联合检测的敏感性及准确性明显高于单项检测(P<0.05)。结论联合检测BALF及血清中的SF、CA-199、CEA对于鉴别肺部良、恶性疾病有较好的临床价值,对肺癌的早期诊断提供良好手段。
Objective To explore the diagnostic value of lung cancer of serum ferritin (SF), carbohydrate antigen (CA-199) and carcinoembryonic antigen (CEA) in bronchoalveolar lavage fluid (BALF) and serum. Methods Measures were made and analyzed on SF, CA-199, CEA in BALF and serum of 60 patients with lung cancers and 68 patients with benign lung diseases. Results Values of SF, CA-199, CEA in BALF and serum concentration in lung cancer was significantly higher than those in benign lung diseases (P 〈 0.001 ). Values of SF, CA-199, CEA in BALF concentration were higher than the serum in lung cancer ( P 〈 0. 01 ). The sensitivity and accuracy of combined measurement were obviously higher than those using single measurement ( P 〈 0. 05 ). Conclusion Combined measurement of SF, CA-199, CEA in BALF and serum has a preferable clinical value in differential diagnosis of benign and malignant lung diseases. It provides useful information for early diagnosis of disease in patients with lung cancer.
出处
《临床肺科杂志》
2007年第7期667-668,共2页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
支气管肺泡灌洗液
铁蛋白
糖链抗原199
癌胚抗原
lung cancer
bronchoalveolar lavage fluid (BALF)
serum ferritin
carbohydrate antigen
carcinoembryonic antigen