重症肺炎抗生素降阶梯疗法的疗效观察

Observation on the efficacy of de-escalation therapy in treatment of severe pneumonia

目的评价重症肺炎采用抗生素降阶梯疗法的疗效。方法60例重症肺炎患者随机分为治疗组及对照组,治疗组30例采用抗生素降阶梯疗法,与对照组比较疗效。结果两组死亡率、ICU住院时间、机械通气时间、总住院时间均具有显著性差异(P<0.05,P<0.01)。结论抗生素降阶梯疗法对重症肺炎具有良好疗效。

Objective To investigate the efficacy of de-escalation therapy in treatment of severe pneumonia. Methods 60 patients with severe pneumonia were randomly divided into two groups, a treatment group of 30 cases receiving antibiotic de - escalation therapy and a control group of 30 cases receiving antibiotic traditional treatment. The curative effects were evaluated after treatment. Results There were significant differences in mortality, the total duration of ICU-stay, the mechanical ventilation time and the total duration of hospital-stay between the two groups （ P 〈 0.05, or P 〈 0.01 ）. Conclusion Antibiotic de-escalation therapy has a better effect on severe pneumonia.