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拉咪夫定联合小剂量高价人乙肝免疫球蛋白预防肝移植术后乙肝病毒再感染21例临床报道

Prophylaxis of reinfection of HBV with low-dose HBIg and lamivudine after liver transplantation
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摘要 目的探讨拉咪夫定联合小剂量高价人乙肝免疫球蛋白方案预防肝移植术后乙肝病毒再感染的临床疗效。方法回顾性研究21例乙肝病毒相关终末期肝病患者行肝移植术后联合应用拉咪夫定、小剂量高价人乙肝免疫球蛋白的临床资料,分析总结该方案对预防肝移植术后乙肝病毒再感染的疗效。结果2例肝移植术后发生乙肝病毒再感染,其余19例病毒标志物检查为阴性。结论拉咪夫定联合小剂量高价人乙肝免疫球蛋白方案可经济、有效地预防乙肝病毒相关终末期肝病肝移植术后乙肝病毒再感染。 Objective To investigate the effect of combined antiviral therapy with lamivudine and low-dose HBIg on reinfection of hepatitis B virus （HBV） in orthotopic liver transplantation （OLT） recipients. Methods The clinical data of 21 liver transplantation recipients were analyzed retrospectively. Result Two recipients reinfected by HBV, and other patients showed negative serum HBV. Conclusion Lamivudine combined with low-dose HBIg may be useful in preventing the reinfection of HBV after OLT.
作者 杨明 陈佑江 文明波 刘祥德
机构地区 解放军第 解放军第 第三军医大学西南医院全军肝胆外科研究所
出处 《重庆医学》 CAS CSCD 2007年第11期1065-1066,1068,共3页 Chongqing medicine
关键词 肝移植 乙型肝炎病毒 再感染 OLT HBV reinfetion
分类号 R657.3 [医药卫生—外科学]
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参考文献9

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二级参考文献22

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共引文献17

重庆医学
2007年 第11期

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