低出生体重危险因素Logistic回归分析

Multinomial logistic regression analysis on risk factors for low birth weight

目的探讨不同原因低出生体重儿发生的危险因素。方法对90名低出生体重儿(早产低出生体重儿42名,足月低出生体重儿48名)和250名正常对照组婴儿进行相关因素调查,采用多项式Logistic回归分析法分析低出生体重发生的危险因素。结果母亲有急性羊膜炎及阴道流夜pH值使试纸变色是早产低出生体重儿发生的危险因素(OR=1.584,7.727,P<0.01);与足月低出生体重儿发生率呈正相关的因素有:宫颈分泌物PCR解脲支原体抗原(UU Ag)阳性和发生胎儿宫内窘迫(OR=3.988,0.580,P<0.001,0.05);与2者均有关的因素是:血清解脲支原体抗体(UU Ab)IgM阳性、血清解脲支原体抗体(UU Ab)IgG阳性、胎盘解脲支原体(UU)培养阳性和孕周等。结论低出生体重发生是多种因素联合作用造成的,尤其是母亲受到感染时,应采取综合措施降低低出生体重儿的发生率。

Objective To investigate the risk factors for low birth weight newborns. Methods 90 low birth weight newborns and 250 infants of the control group were investigated using questionnaire. Multinomial logistic regression analysis was applied to analyze the related risk factors for low birth weight. Results There were positive relations between preterm low birth weight newborns and mothers who induced impatient amnion and liquid in the vagina pH to make the paper change countenance（ OR = 1. 584,7. 727 ,P 〈0.01 ）. The factors which could increase the risk of low birth weight newborns included womb PCR UU Ag （ ＋ ） and the infant hard - pressed（ OR = 3.988,0.580 ,P 〈0.001,0.05 ）. The factors which were related to preterm low birth weight newborns and term low birth weight newborns were multiparity, serum UU Ab IgM（ ＋ ） and IgG（ ＋ ） and placenta UU（ ＋ ） , etc. Conclusion Low birth weight was caused by many factors. Comprehensive measure should be taken to reduce morbidity of low birth weight newborns.