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过敏性紫癜患儿血浆血管内皮生长因子和可溶性血管细胞黏附分子-1的表达 被引量:3

Expression of Vascular Endothelial Growth Factor and Soluble Vascular Cell Adhesion Molecule-1 in Children with Henoch-Schonlein Purpura
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摘要 目的探讨血管内皮生长因子(VEGF)和可溶性血管细胞黏附分子-(sVCAM-1)在过敏性紫癜(HSP)儿童表达的意义。方法HSP患儿58例。其中急性期30例,缓解期28例。正常对照组23例。采用固相酶联免疫吸附法(ELISA)分别检测其血浆VEGF、sVCAM-1水平,并进行两两比较和相关分析。结果HSP急性期患儿血浆VEGF、sVCAM-1水平明显高于缓解期和对照组(Pa<0.01),且二者呈正相关(r=0.939P<0.001)。结论VEGF、sVCAM-1可能参与HSP发病过程,对病情发展及预后判断有一定意义。 Objective To study the expression and clinical significance of vascular endothelial growth factor(VEGF) and soluble vascular cell adhesion molecule - 1 ( sVCAM - 1 ) in children with Henoch - Schonlein purpura(HSP). Methods The levels of plasma VEGF and sVCAM - 1 were measured in 58 children with HSP and 23 normal children by enzyme - linked immunosorbent assay ( ELISA ), respectively. Results The plasma levels of VEGF and sVCAM - 1 of HSP children at acute stage were significantely higher than those of HSP children at the remission stage and those of the controls ( Pa 〈 0.01 ). The plasma levels of VEGF of HSP children at the acute stage were positively correlated with the levels of sVCAM - 1 (r = 0. 939 P 〈 0. 001 ). Conclusion VEGF and sVCAM - 1 may play a crucial role in pathogenesis of HSP.
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2007年第9期682-682,684,共2页 Journal of Applied Clinical Pediatrics
关键词 血管内皮生长因子 可溶性血管细胞黏附分子-1 紫癜 过敏性 儿童 vascular endothelial growth factor soluble vascular cell adhesion molecule - 1 Henoch - Schonlein purpura child
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