甘露聚糖肽对预防特发性血小板减少性紫癜复发的作用

Preventive Effect of Mannatide on Relapsing of Idiopathic Thrombocytoperlic Purura

目的观察甘露聚糖肽对特发性血小板减少性紫癜(ITP)患儿继发感染、复发的影响。方法初治ITP患儿120例随机分为甘露聚糖肽治疗组和单纯激素对照组。对照组采用地塞米松针静脉滴注3d,后改为口服泼尼松;治疗组在此基础上口服甘露糖肽片,疗程1个月。观察治疗阶段临床出血症状控制时间及血小板变化情况,继发感染率、感染控制时间、复发率及用药前后血清IgG、IgA、IgM变化。结果二组出血症状控制时间及血小板上升至正常值时间无显著差异(Pa>0.05);继发感染率和复发率、感染后控制时间均显著低于对照组。用药后治疗组血清IgG、IgA上升显著,对照组无明显变化;IgM无显著变化。结论甘露聚糖肽佐治ITP有预防和降低感染,减少和预防复发的作用,增强患儿细胞和体液免疫功能。

Objective To observe the preventive effect of mannatide on infection and relapse of idiopathic thrombocytopenic purura （ITP） . Methods One hundred and twenty children with ITP were randomly divided into mannatide treatment group and prednisone control group. Control group venous dexamethasone of 3 d ; then treated by prednisone. Treatment group added mannatide tablets for 1 month. The rates of remission clinical blood, platelet,control time, complicated infection and relapse rates were observed. The levels of plasma immunoglobulin（Ig） G , IgA, IgM were determined before and after mannatide treatment. Results The rate of clinical blood, platelet ,control time, infection time was not different in 2 groups. The rates of infection complicated and relapse were all significant lower than that in control group. The plasma IgG,IgA significantly increased than that in control group. The plasma IgM had no significant difference. Conclusion Vaccine therapy can be helpful in protecting and decreasing infection, diminishing relapse of children with ITP, and improve the level of IgG, IgA, and thus improve their immune function.