反复呼吸道感染儿童细胞免疫与体液免疫状况

Cellular and Humoral Immunity in Children with Recurrent Respiratory Tract Infection

目的探讨反复呼吸道感染(RRI)患儿细胞与体液免疫状况,为临床进行免疫治疗提供依据。方法用流式细胞仪对23例RRI患儿进行外周血淋巴细胞亚群检测;同时进行免疫球蛋白(IgA、IgG、IgM)及补体C3、C4水平检测。结果与健康人群比较,RRI患儿血清IgG及IgA各有1例降低,血清IgM降低7例;补体C3降低3例,C4降低1例。RRI患儿外周血CD8较健康对照组明显增高(P=0),CD4/CD8较健康对照组明显降低(P=0.002)。结论RRI患儿存在体液免疫功能降低,细胞免疫功能失调亦非常显著。

Objective To explore the cellular and humoral immunity in children with recurrent respiratory tract infection（RRI）. Methods Fresh peripheral blood samples were treated and run through the flow cytometry, the percentage of lymphocytes subsets were acquired using Simuhest software simulaneously. Immunoglobulin IgA, IgG, IgM and complement C3 and C4 were measured. Results The levels of IgG and IgA in the RRI group were lower than the normal reference value in only 1 patient respectively. The level of IgM decreased in 7cases. Complement C3 and C4 decreased in 3 and 1 patients, respectively. The percentage of CD8 in the RRI group was higher than that in healthy control group （P = 0）, and the CD4/CD8 was obviously lower than that in healthy control group（ P = 0. 002 ）. Conclusions The disorder of cellular and humoral immunity are existing and cell - mediated immune disorder is more obviously in RRI. The immune - modulation agents are necessary in the prevention and treatment for RRI.