重症肺炎新生儿酸碱平衡紊乱分析

Analysis of Acid-Base Disturbance Caused by Severe Pneumonia in Newbern Infants

目的分析重症肺炎新生儿氧疗前后的酸碱平衡紊乱情况。方法分别在氧疗前和氧疗后12h抽取重症肺炎患儿静脉血行血清电解质检测,动脉血行血气分析,比较重症肺炎患儿氧疗前后其变化,并与对照组比较氧疗前酸碱平衡紊乱情况。结果重症肺炎治疗前45例均出现酸碱平衡紊乱,且以剩余碱(AG)增高的代谢性酸中毒并呼吸性酸中毒为主,明显高于对照组(t=1.27P<0.05)。重症肺炎患儿氧疗后酸中毒例数较氧疗前明显减少(t=3.28P<0.01)。结论新生儿重症肺炎致酸碱平衡紊乱以AG增高的酸中毒为主,不宜盲目补碱。

Objective To analyze the type of acid - base disturbance caused by severe pneumonia in newborn infants. Methods Venous blood of neonate with severe pneumonia （SP group） were collected to detect serum electrolyte and blood gas analysis 12 hours before and after oxygen therapy. The results of serum electrolyte and blood gas were compared 12 hours before and after oxygen therapy ,and the results of acid - base disturbance between SP group and control groups were compared. Results There were mostly metabolic acidosis incorporated respiratory acidosis in all neonate in SP group,which were with increased anion gap （AG） and obviously higher than that of control group （ t = 1.27 P 〈 0.05 ）. The number of infants with mixed acidosis and increased AG was obviously reduced after oxygen therapy in SP group （ t = 3.28 P 〈0. 01 ）. Conclusion Acid - base disturbance caused by severe pneumonia is acidosis with increased AG and not suitable for given base.