幽门螺杆菌与心脏X综合征的关系初探

Association of helicobacter pylori infection with cardiac syndrome X

目的初步观察幽门螺杆菌(HP)感染与心脏X综合征的关系。方法应用尿素呼气试验(UBT)对心脏X综合征组和年龄、性别匹配的对照组进行HP检测,确证有无HP感染;分别测定两组高敏C反应蛋白(hs-CRP)和纤维蛋白原(FIB)的水平。结果心脏X综合征组的HP感染率明显高于对照组(85.2%比46.7%,P=0.002),其hs-CRP水平也高于对照组(4.09±0.78比1.49±0.43,P<0.001),差异均有统计学意义;而两组间的FIB水平差异无统计学意义。结论HP感染与心脏X综合征的发病机理有关。

Objective To explore association of Helicobacter pylori （HP） infection with cardiac syndrome X. Methods HP infection was detected by urea breath test （UBT） in patients with cardiac syndrome X compared with a sex- and age-matched control group, and the level of high sensitivity C reactive protein （hs- CRP） and fibrinogen （FIB） was measured in two groups. Results The results indicated that 85.2% of cardiac syndrome X group were positive for HP infection, while only 46.7% of the control group were found to have HP infection （P=0.002）, and hs-CRP was significantly higher in patients with cardiac syndrome X, compared with control group （4.09±0.78 vs 1.49±0.43,P〈0.001 ）. But there was no significant difference in the level of FIB between the two groups. Conclusion There is a probable role for HP infection in the pathogenesis of CSX.