原发性高血压患者体液免疫水平的变化及影响因素

Humoral immune level and distributive speciality in essential hypertension

目的观察原发性高血压患者的体液免疫水平及其分布特征。方法随机选取我院住院的原发性高血压患者112(男68,女44)例为观察对象,以同期的健康体检者73例(排除继发性高血压及其他免疫系统疾病)为对照,分析不同性别、年龄、病期、脉压差及不同并发症组各组间体液免疫水平及其分布特征。结果与对照组相比较,男女原发性高血压患者IgG水平显著增高(P<0.05);且随着年龄的增长、病情的加重,血清IgG和IgA的含量及抗核抗体(ANA)和核抗原抗体(ENA)检出率显著增加(P<0.05)。脉压差<60mmHg者IgG、IgA的水平显著高于对照组(P<0.05);并发心脑血管损害者血清IgG和ANA的含量异常升高(P<0.05)。结论原发性高血压患者体液免疫水平升高,其分布与年龄、高血压分级、脉压差和并发症有关。

AIM To assess the humoral immune level and distributive speciality in essential hypertension. METHODS Study was performed on 112 patients （68males, 44females） with mild or moderate essential hypertension. The patients were randomly divided into 2 groups and 73 healthy volunteers were chosen as the control group. The contents of IgG, IgA, IgM, C3, C4, ANA and ENA were measured. RESULTS IgG was higher in the hypertensive subjects than in the controls （ P 〈 0.05 ）. IgG, IgA, and the positive rate of ANA and ENA increased with the age and hypertension progression （P 〈 0.05 ）. IgG and IgA in patients with difference between systolic pressure and diastolic pressure 〈 60 mmHg were significantly higher than those in control group （ P 〈 0.05 ）. IgG and ANA of patients with brain and cardiovascular injuries were significantly higher than those in patients without these injuries （ P 〈 0.05 ）. CONCLUSION The increase in IgG, IgA, ANA and ENA suggests the possible involvement of humoral immunity in the pathogenesis or progression of essential hypertension.