阿贝西普的药理作用与临床研究

Pharmacology and clinical study of abatacept in the treatment of rheumatoid arthritis

阿贝西普是一种选择性共刺激调节剂,用于缓解病情抗风湿药疗效不佳的中至重度活动性类风湿性关节炎(RA)的成年患者,以改善RA的症状和体征,减缓骨结构的损伤进程,提高患者的机体功能。现对其药理作用、药动学、临床研究及不良反应进行综述。

Abatacept, a selective costimulation modulator, has been used for treatment of moderately to severely active RA in adult patients who had an inadequate response to DMARDs. The clinical studies found that this agent reduces signs and symptoms of RA, slows down the progression of structural damage, and improves physical functions of patients. This article reviews the pharmacology, pharmacokinetics, clinical studies and safety profile of abatacept.