胰岛素泵治疗对2型糖尿病患者胰岛β细胞功能的影响

Effect of short-term insulin pump treatment on beta-cell function and insulin resistance in type 2 diabetic patient

目的观察短期胰岛素泵治疗对2型糖尿病患者胰岛β细胞功能及胰岛素抵抗的影响。方法用胰岛素泵对63例诊断时间为2-4年的2型糖尿病患者进行2周的持续皮下胰岛素输注（CSII）,分析比较治疗前后空腹（FPG）及餐后2h血糖（2hPG）、糖化血红蛋白A1c（HbA1c）,空腹胰岛素（FIns）,空腹C-肽（FC-P）,胰岛素分泌指数（Homa-β）、胰岛素抵抗指数（Homa-IR）。结果CSII治疗能快速稳定控制血糖,治疗2周后FINS,FC-P及Homa-β明显上升,Homa-IR明显下降（P〈0.01）。结论短期CSII治疗对诊断2-4年的T2DM有快速稳定控制血糖、改善胰岛β细胞功能和降低胰岛素抵抗的作用。

Objective To observe the effect of short - term intensive insulin pump on beta - cell function and insulin resistance in type 2 diabetic patients. Methods Sixty - three type 2 diabetic patients with a duration of illness of 2 - 4 years were treated by continuous subcutaneous insulin infusion （CSII） for two weeks. The levels of fast plasma glucose （FPG）, 2 hours postpradial glucose （2hPG）, and glycosylated hemoglobin Ale （HbAIe）, fast insulin （Fins） and C - peptide （FC - P）, insulin secretion indexes （ HOMA - B） and insulin resistance index （ HOMA - IR） were determined and compared before and after CSII. Results The level of blood sugar was well stably eontroled by CSII. The levels of Fins, FC - P, HOMA - B were increased significantly two weeks after intensive treatmetn with CSII. The HOMA- IR were decreased significantly. Conclusion Short- term CSII intensive treatment can stably control the level of blood sugar, improve the function of beta - cell and reduce the resistance to insulin in type 2 diabetic patients.