磷霉素与氨基糖苷类药物联合应用的研究进展

The progressive study of the combination of fosfomycin and aminoglycosides

磷霉素不同于任何其他抗菌药物,具有独特化学结构与抗菌机制,与一些抗菌药物联用呈现协同作用;氨基糖苷类药物抗菌谱广、杀菌活性强,但耳、肾毒性限制了其临床应用。本文拟通过药效学特性、药物安全性以及细菌生物被膜3部分内容,综述磷霉素与氨基糖苷类药物联合应用的研究进展,以期为临床联合用药提供参考,促进临床安全合理用药。

Fosfomycin possess distinct chemical constitution and antibiosis mechanism other than any other antibacterials, and has sysnergistic effect with other antibacterials.Aminoglycosides has wide antibacterial spectrum and powerful bactericidal activity,but ototoxicity and renal toxicity limit its clinical appli cation.This article aims to offer information for clinical by reviewed the progressive study of the combination of fosfomycin and aminoglycosides -including three sectors：pharmacodynamics characteristics,drug safety,bacterial biofilm-to ensure the rational use of drug in clinical.