IFN-α在原发性舍格伦综合征患者唇腺组织中的表达

The expression of interferon-α in the labial glands of patients with primary SjOgren's syndrome

目的:检测原发性舍格伦综合征患者唇腺组织中IFN-α的表达水平,探讨IFN-α在原发性SS发病中的作用。方法:对37例原发性SS患者和24例非SS患者的唇腺组织进行IFN-α免疫组化染色,比较分析其在两组之间的差异。使用SAS6.12统计软件包对数据进行t检验。结果:37例原发性SS患者中,22例(59.46%)表达阳性,15例(40.54%)表达阴性;24例非SS组患者中3例(12.5%)表达阳性,其余21例(87.5%)均表达阴性。2组之间有显著差异。结论:IFN-α在原发性舍格伦综合征患者唇腺组织中存在表达异常。

PURPOSE： To investigate the interferon-or levels in the labial glands of patients with primary Sjogren＇s syndrome（pSS）,and explore preliminarily the correlation between pSS and interferon-or. METHODS： Immunohistochemistry was used to examine interferon-or positive cells in labial glands in 34 patients with pSS and 27 patients with non-pSS. SAS 6.12 software package was used for student＇s t test. RESULTS： The positive expressions of interferon-or cells in the labial glands were found in 22 out of 37 patients （59.46%） with pSS, the other 15 （40.54%） patients with pSS were negative. The positive expressions of interferon-or cells in the labial glands were detected in 3 out of 24 patients （12.5%） with non-pSS, the other 21 （87.5%） patients with non-pSS were negative. There was significant difference between pSS and non-pSS. CONCLUSIONS： The study reveals that the interferon-or in the labial glands of patients with pSS were abnormally expressed.