肾内小动脉重构的研究现状

Remodeling of intrarenal small arteries

血管重构(VR)是引起高血压、糖尿病等血管疾病和循环功能紊乱的病理基础,其能促进靶器官损害和功能衰竭,提升疾病危险分层,故逆转VR已成为临床治疗靶向之一。肾脏是包括高血压、糖尿病等多种疾病的重要靶器官,肾内小动脉决定了肾脏血流灌注的绝大部分阻力,其重构直接影响肾脏血流供应,引发神经内分泌过度激活及其恶性循环,促进肾脏及其他靶器官损害及功能衰竭,影响预后。本文对VR尤其肾内小动脉VR研究现状及其重要意义作一综述。

Vascular remodeling is not only the pathologic cause of circulation dysfunction and vascular disease such as hypertension and diabetes, but also can accelerate the process of dysfunction and failure of target organs. To reverse vascular remodeling has been one of the clinical aims. Kidney is one of the critical common target organs of many kinds of diseases such as diabetes and hypertension. The main part of the intrarenal resistance comes from the intrarenal small arteries, and the remodeling of intrarenal small arteries can reduce the blood supply of kidney and lead to excessive activation of neuroendocrine system as well their vicious cycle, resulting a terrible prognosis together with kidney and other target organs failure. This paper reviews the advance of vascular remodeling especially in the intrarenal small arteries.