复方青黄胶囊治疗慢性粒细胞白血病6例临床报道

Case reports on 6 patients with chronic myelocytic leukemia treated with complex capsules of Qinghuang

目的:研究复方青黄胶囊对慢性粒细胞白血病的临床疗效。方法:采用青黛、雄黄等制备成中药复方胶囊,进行临床慢性粒细胞白血病志愿者服药治疗研究,观察复方青黄胶囊对患者治疗前后血象及对预后和生存的影响。结果:6例患者均获得完整的随访资料,接受复方青黄胶囊治疗的慢性粒细胞白血病患者4例完全缓解,2例部分缓解;6例患者均未出现急性病变,1例已存活16年。结论:复方青黄胶囊对慢性粒细胞白血病有较好治疗效果,且副作用少,为中药砷剂治疗慢性粒细胞白血病提供了临床参考。

AIM： To investigate the clinical effects of complex capsules of Qinghuang in the treatment of patients with chronic myelocytic leukemia （CML）. METHODS： The complex capsules of Qinghuang are composed of indigo naturalis, realgar, etc. The volunteers with chronic myelocytic leukemia received the clinical therapy of complex capsules of Qinghuang. The analysis of hemogram and evaluation of survival and prognosis in patients treated with and without complex capsules of Qinghuang were observed. RESULTS： We got the entire information and data of follow-up visit of patients after they were treated with complex capsules of Qinghuang for a long time. Among 6 patients, 4 of them were complete remission （CR） and 2 were partial remission （PR）, and 1 patient had survived for 16 years. All patients did not deteriorate into acute transformation phase. CONCLUSION： The complex capsules of Qinghuang have a good therapeutic efficacy on the treatment of patients with chronic myelocytic leukemia, and they have only some gentle side effects. The present study provides some clinical evidences for the treatment of CML with traditional Chinese medicine and arsenical in the future.